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26326 RNP/SmRNP Antibodies

RNP/SmRNP Antibodies
Test Code: RNP
Synonyms/Keywords

​SMRNP, ENA, Extractable Nuclear Antibodies, RNP

Test Components

​RNP and SmRNP Antibodies

Useful For

​A confirmatory test for the evaluation of patients with signs and symptoms of MCTD and SLE. Anti-RNP antibodies include RNP and SmRNP. Frequently associated with nuclear coarse speckled patterns by ANA IFA.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT) or Serum Separator Tube (SST)​1.0 mL​0.5 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​Refrigerated​7 days
​Frozen​> 7 days
Rejection Criteria
​Gross Lipemia
​Gross Hemolysis
​Heat inactivated samples

 

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday​1 day​Multiplex Flow Immunoassay/ Bio-Rad BioPlex 2200
Reference Range Information
Performing LocationReference Range
​Marshfield

​Negative <1.0 AI

Analytical measuring range is 0.2-8.0 AI (Antibody Index)

Interpretation

​Positive result(s) support diagnosis of mixed connective tissue disease, which resembles SLE but is not accompanied by renal involvement.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86235​2​Antibody to extractable nuclear antigen
Synonyms/Keywords

​SMRNP, ENA, Extractable Nuclear Antibodies, RNP

Test Components

​RNP and SmRNP Antibodies

Ordering Applications
Ordering ApplicationDescription
CernerRNP/​SmRNP Antibodies
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT) or Serum Separator Tube (SST)​1.0 mL​0.5 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​Refrigerated​7 days
​Frozen​> 7 days
Rejection Criteria
​Gross Lipemia
​Gross Hemolysis
​Heat inactivated samples

 

Useful For

​A confirmatory test for the evaluation of patients with signs and symptoms of MCTD and SLE. Anti-RNP antibodies include RNP and SmRNP. Frequently associated with nuclear coarse speckled patterns by ANA IFA.

Test Components

​RNP and SmRNP Antibodies

Reference Range Information
Performing LocationReference Range
​Marshfield

​Negative <1.0 AI

Analytical measuring range is 0.2-8.0 AI (Antibody Index)

Interpretation

​Positive result(s) support diagnosis of mixed connective tissue disease, which resembles SLE but is not accompanied by renal involvement.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday​1 day​Multiplex Flow Immunoassay/ Bio-Rad BioPlex 2200
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86235​2​Antibody to extractable nuclear antigen
For most current information refer to the Marshfield Laboratory online reference manual.