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26326 RNP/SmRNP Antibodies

RNP/SmRNP Antibodies
Test Code: RNP
Synonyms/Keywords

​SMRNP, ENA, Extractable Nuclear Antibodies, RNP

Test Components

​RNP and SmRNP Antibodies

Useful For

Diagnosis and prognosis of rheumatoid arthritis. A seropositive rheumatoid arthritis generally has a more favorable prognosis than seronegative form. This "rheumatoid factor" is not specific for rheumatoid arthritis; it also appears in serum from patients with Connective Tissue Disease, chronic inflammatory and infectious diseases, pulmonary fibrosis, liver disease and acute viral infections.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. 

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT) or Serum Separator Tube (SST)​​1.0 mL​0.5 mL​0.5 mL
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​Refrigerated​7 days
​Frozen​3 months
Rejection Criteria
​Gross Lipemia
​Gross Hemolysis
​Heat inactivated samples

 

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday​1 day​Multiplex Flow Immunoassay/ Bio-Rad BioPlex 2200
Reference Range Information
Performing LocationReference Range
​Marshfield

​Negative ≤ 13 IU/mL​

Analytical measuring range is 0.2-8.0 AI (Antibody Index)

Interpretation

​Positive result(s) support diagnosis of mixed connective tissue disease, which resembles SLE but is not accompanied by renal involvement.

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​86235​​2​Antibody to extractable nuclear antigen​
Synonyms/Keywords

​SMRNP, ENA, Extractable Nuclear Antibodies, RNP

Test Components

​RNP and SmRNP Antibodies

Ordering Applications
Ordering ApplicationDescription
CernerRheumatoid Factor, IgM​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT) or Serum Separator Tube (SST)​​1.0 mL​0.5 mL​0.5 mL
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​Refrigerated​7 days
​Frozen​3 months
Rejection Criteria
​Gross Lipemia
​Gross Hemolysis
​Heat inactivated samples

 

Useful For

Diagnosis and prognosis of rheumatoid arthritis. A seropositive rheumatoid arthritis generally has a more favorable prognosis than seronegative form. This "rheumatoid factor" is not specific for rheumatoid arthritis; it also appears in serum from patients with Connective Tissue Disease, chronic inflammatory and infectious diseases, pulmonary fibrosis, liver disease and acute viral infections.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. 

Test Components

​RNP and SmRNP Antibodies

Reference Range Information
Performing LocationReference Range
​Marshfield

​Negative ≤ 13 IU/mL​

Analytical measuring range is 0.2-8.0 AI (Antibody Index)

Interpretation

​Positive result(s) support diagnosis of mixed connective tissue disease, which resembles SLE but is not accompanied by renal involvement.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday​1 day​Multiplex Flow Immunoassay/ Bio-Rad BioPlex 2200
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
​86235​​2​Antibody to extractable nuclear antigen​
For most current information refer to the Marshfield Laboratory online reference manual.