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25123 Connective Tissue Disease Panel

Connective Tissue Disease Panel
Test Code: CTDP
Synonyms/Keywords
​Rheumatoid Arthritis, RA, RA-IgM, Lupus, SLE, CREST syndrome, Sjogren's syndrome, scleroderma, polymyositis, dermatomyositis​
Test Components
This panel tests for Rheumatoid Factor (RA-IgM), Cyclic Citrullinated Peptide (CCP), and Antinuclear antibodies (ANA).​
Useful For
For the screening and diagnosis of patients with symptoms of mixed connective tissue diseases such as systemic lupus erythematosus, systemic sclerosis, myositis, Sjogren's syndrome, and rheumatoid arthritis. See the Mixed Connective Tissue Disease Panel Algorithm for suggested follow-up testing.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.5  mL​ 1.0 mL​ 1.0 mL​
Collection Processing Instructions

​​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 2 days​
Frozen > 2 days​
Rejection Criteria
Gross hemolysis
Gross lipemia​
Heat inactivated samples​
Gross icterus
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2 days​

RA: Turbidimetric Method (Binding Site/Optilite)

ANA: Indirect Immunofluorescence

CCP:Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200 ​

Reference Range Information
Performing Location Reference Range
Marshfield ​

RA: <=13 IU/mL

ANA: Negative

CCP: 0 - 2.9 IU/mL ​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86200​ ​ 1​ CCP​ ​
86431​ ​ ​1 RA​ ​
86038 ​ ​ ​1 ANA​ ​
Synonyms/Keywords
​Rheumatoid Arthritis, RA, RA-IgM, Lupus, SLE, CREST syndrome, Sjogren's syndrome, scleroderma, polymyositis, dermatomyositis​
Test Components
This panel tests for Rheumatoid Factor (RA-IgM), Cyclic Citrullinated Peptide (CCP), and Antinuclear antibodies (ANA).​
Ordering Applications
Ordering Application Description
​Cerner ​Connective Tissue Disease Pnl
​COM ​Connective Tissue Disease Pnl
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.5  mL​ 1.0 mL​ 1.0 mL​
Collection Processing

​​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 2 days​
Frozen > 2 days​
Rejection Criteria
Gross hemolysis
Gross lipemia​
Heat inactivated samples​
Gross icterus
Useful For
For the screening and diagnosis of patients with symptoms of mixed connective tissue diseases such as systemic lupus erythematosus, systemic sclerosis, myositis, Sjogren's syndrome, and rheumatoid arthritis. See the Mixed Connective Tissue Disease Panel Algorithm for suggested follow-up testing.
Test Components
This panel tests for Rheumatoid Factor (RA-IgM), Cyclic Citrullinated Peptide (CCP), and Antinuclear antibodies (ANA).​
Reference Range Information
Performing Location Reference Range
Marshfield ​

RA: <=13 IU/mL

ANA: Negative

CCP: 0 - 2.9 IU/mL ​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2 days​

RA: Turbidimetric Method (Binding Site/Optilite)

ANA: Indirect Immunofluorescence

CCP:Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200 ​

For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86200​ ​ 1​ CCP​ ​
86431​ ​ ​1 RA​ ​
86038 ​ ​ ​1 ANA​ ​
For most current information refer to the Marshfield Laboratory online reference manual.