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23299 Ribosomal P Antibody

Ribosomal P Antibody
Test Code: RIBOP
Synonyms/Keywords
​​Ribosomal P, Anti-Ribosome P Antibodies, Ribosomal P Antibodies, Ribosome Antibody
Useful For
A confirmatory test for the evaluation of patients with signs and symptoms of SLE associated with neuropsychiatric involvement. Ribosomal P antibodies may be detected by very dense fine granular cytoplasmic pattern by ANA IFA.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen​ ​> 7 days
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Test Information

Ribosomal P antibodies occur with active SLE (systemic lupus erythematosus), and are seen in association with CNS involvement and cardiolipin antibodies.

This tests aids in the differential diagnosis of neuropsychiatric symptoms in patients with SLE.

Since patients with SLE may manifest signs and symptoms of CNS diseases including neuropsychiatric symptoms, the presence of antibodies to ribosome P protein may be useful in the differential diagnosis of such patients. Other causes of CNS symptoms in patients with SLE include thrombosis with or without antibodies to phospholipid antigens and iatrogenic effects from treatment with corticosteroid drugs.
A positive result is consistent with the diagnosis of lupus erythematosus, and may indicate the presence of central nervous system involvement.

Reference Range Information
Performing Location Reference Range
Marshfield ​

Negative: <1.0​

Analytical measuring range 0.2 - 8.0 AI (Antibody Index) ​

Interpretation
A positive results supports the diagnosis of SLE in the case of neuropsychiatric lupus. ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
Synonyms/Keywords
​​Ribosomal P, Anti-Ribosome P Antibodies, Ribosomal P Antibodies, Ribosome Antibody
Ordering Applications
Ordering Application Description
​Cerner ​Ribosomal P Antibody​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen​ ​> 7 days
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Useful For
A confirmatory test for the evaluation of patients with signs and symptoms of SLE associated with neuropsychiatric involvement. Ribosomal P antibodies may be detected by very dense fine granular cytoplasmic pattern by ANA IFA.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​
Reference Range Information
Performing Location Reference Range
Marshfield ​

Negative: <1.0​

Analytical measuring range 0.2 - 8.0 AI (Antibody Index) ​

Interpretation
A positive results supports the diagnosis of SLE in the case of neuropsychiatric lupus. ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.