"Ribosomal P antibodies occur with active SLE (systemic lupus erythematosus), and are seen in association with CNS involvement and cardiolipin antibodies.
This tests aids in the differential diagnosis of neuropsychiatric symptoms in patients with SLE.
Since patients with SLE may manifest signs and symptoms of CNS diseases including neuropsychiatric symptoms, the presence of antibodies to ribosome P protein may be useful in the differential diagnosis of such patients. Other causes of CNS symptoms in patients with SLE include thrombosis with or without antibodies to phospholipid antigens and iatrogenic effects from treatment with corticosteroid drugs. A positive result is consistent with the diagnosis of lupus erythematosus, and may indicate the presence of central nervous system involvement."