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23298 Chromatin Antibodies

Chromatin Antibodies
Test Code: CHROMA
Synonyms/Keywords
Histone​
Useful For
A positive result supports diagnosis of SLE, drug-induced lupus erythematosus, and juvenile idiopathic arthritis. Can be ordered as a confirmatory test after a positive homogeneous pattern by ANA IFA.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen​ 6 months
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Test Information
Chromatin reactive autoantibody is unique to histone-DNA complexes and may not be reactive to individual components.​
Reference Range Information
Performing Location Reference Range
Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 -8.0 AI (Antibody Index) ​

Interpretation

​A positive result supports diagnosis of SLE.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
Synonyms/Keywords
Histone​
Ordering Applications
Ordering Application Description
​Cerner ​Chromatin Antibodies
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.3 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen​ 6 months
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Useful For
A positive result supports diagnosis of SLE, drug-induced lupus erythematosus, and juvenile idiopathic arthritis. Can be ordered as a confirmatory test after a positive homogeneous pattern by ANA IFA.

See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. ​​
Reference Range Information
Performing Location Reference Range
Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 -8.0 AI (Antibody Index) ​

Interpretation

​A positive result supports diagnosis of SLE.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86235​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.