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23160 Cyclic Citrullinated Peptide Antibodies

Cyclic Citrullinated Peptide Antibodies
Test Code: CCP
Synonyms/Keywords
​CCP, Rheumatoid Arthritis​, Avise MCV
Useful For
Detection of CCP antibodies is used as an aid in the diagnosis of rheumatoid arthritis.  Measurements of anti-CCP may provide important information regarding the severity and prognosis of the disease.​
​
See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. 
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.4 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection. 

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia
​Gross Icterus
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Test Information
A positive result for CCP antibodies indicates a high likelihood of RA. However, not all RA patients are positive for CCP antibodies. Results of this assay should be used in conjunction with clinical findings and other serological tests.​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative: <3.0 U/mL  ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86200 ​ ​ 1​ ​ ​
Synonyms/Keywords
​CCP, Rheumatoid Arthritis​, Avise MCV
Ordering Applications
Ordering Application Description
​Centricity ​Cyclic Citrullinated Peptide
​Cerner ​Cyclic Citrulline Peptide
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST) ​ ​ 1.0 mL​ 0.4 mL​ 0.4 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection. 

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia
​Gross Icterus
Useful For
Detection of CCP antibodies is used as an aid in the diagnosis of rheumatoid arthritis.  Measurements of anti-CCP may provide important information regarding the severity and prognosis of the disease.​
​
See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. 
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative: <3.0 U/mL  ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86200 ​ ​ 1​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.