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22306 Centromere Antibodies

Centromere Antibodies
Test Code: CENTB
Synonyms/Keywords
Centromere Antibody, Antinuclear Antibody, ANA​
Useful For
There is an association between centromere antibodies and the clinical CREST (Calcinosis, Raynaud's phenomenon, esophageal disfunction, sclerodactyly, telangictasia) syndrome, considered to be a milder form of scleroderma.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube (RTT) or Serum Separator Tube (SST) ​
1.0 mL​ 0.5 mL 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross lipemia 
Gross hemolysis​
Heat inactivated samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marsfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
 Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 - 8.0 AI (Antibody Index). ​

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86235​
Synonyms/Keywords
Centromere Antibody, Antinuclear Antibody, ANA​
Ordering Applications
Ordering Application Description
​Centricity ​Centromere B Antibodies
​Cerner ​Centromere Antibody Screen
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube (RTT) or Serum Separator Tube (SST) ​
1.0 mL​ 0.5 mL 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross lipemia 
Gross hemolysis​
Heat inactivated samples​
Useful For
There is an association between centromere antibodies and the clinical CREST (Calcinosis, Raynaud's phenomenon, esophageal disfunction, sclerodactyly, telangictasia) syndrome, considered to be a milder form of scleroderma.​
Reference Range Information
Performing Location Reference Range
 Marshfield ​

Negative: <1.0

Analytical measuring range is 0.2 - 8.0 AI (Antibody Index). ​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marsfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86235​
For most current information refer to the Marshfield Laboratory online reference manual.