Anti-Leukocyte Ab, Anti-Leukocyte Antibodies, Anti-Neutrophil, Antigranulocyte Antibodies, Granulocyte Ab, Granulocyte Binding IgG, LAGGN, LAGGT, Leukoagglutinin, Neutrophil Antibodies
GIFT/GAT Interpretation
GIFT Result
GAT Result
*Only a specimen collected before a transfusion reaction is acceptable.
Serum Separator Tube (SST) are NOT acceptable.
Centrifuge and aliquot serum into a plastic vial.
Gross Hemolysis
Testing for patients who receive human monoclonal antibodies like daratumumab may cause false-positive results due to interfering substances. Hemolytic samples have the potential for causing false-positivity and will, therefore, be rejected.
Granulocyte antibodies are induced by pregnancy, prior transfusion, or transplants. These antibodies can cause neutropenia in various autoimmune disorders. Febrile nonhemolytic transfusion reactions and alloimmune neonatal neutropenia may also be caused by granulocyte associated antibodies, including anti-human leukocyte antigen antibodies.
Not applicable
A positive result can be due to anti-granulocyte antibodies and anti-human leukocyte antigen antibodies.
This test cannot distinguish between allo- or autoantibodies, nor can it determine the specificity of the detected antibody. Results should be correlated to clinical history.