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26513 Herpes Simplex Virus (HSV), Molecular Detection, PCR, Blood (HSVPB)

Herpes Simplex Virus (HSV), Molecular Detection, PCR, Blood (HSVPB)
Test Code: HSVPBSO
Synonyms/Keywords

​​Herpes Simplex Virus Detection by Real-Time PCR

HSV (Herpes Simplex Virus) by PCR (Polymerase Chain Reaction)

HSV Detection by Real-Time PCR

HSV PCR

LightCycler HSV​


Useful For

Aiding in the rapid diagnosis of disseminated disease due to herpes simplex virus (HSV)

Qualitative detection of HSV DNA

This test should not be used to screen asymptomatic patients.

​If herpes simplex virus (HSV) is suspected in sources other than blood, order HSVPV / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies.

If HSV is suspected in cerebrospinal fluid, order HSVC / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Spinal Fluid.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/Tube
Acceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

​Whole Blood
​EDTA Lavender Top Tube (LTT)
​1 mL
​0.4 mL
Collection Processing Instructions

Send whole blood specimen in original tube. Do not aliquot.

Specimen Stability Information
Specimen TypeTemperature
Time

​Whole Blood


​Refrigerated (preferred)
​7 days
​Frozen
​7 days
Rejection Criteria

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Interference

This test is intended for patients with evidence of disseminated disease due to herpes simplex virus (HSV). For patients with localized (eg, skin, genital) disease, a swab of suspect lesions should be collected and submitted for real-time polymerase chain reaction (PCR) analysis; HSVPV / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies).  A negative result does not eliminate the possibility of HSV infection.  Although the reference value is typically "negative" for this assay, viral shedding may be detected in asymptomatic individuals. This assay is only to be used for patients with a clinical history and symptoms consistent with HSV infection and must be interpreted in the context of the clinical picture.



Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Mayo Clinic Laboratories
​Monday through Saturday
​Same day/1 to 4 days
​Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization
Reference Lab
Test Information

Herpes simplex virus (HSV) types 1 and 2 cause a variety of clinical syndromes. Anatomic sites infected include the skin, lips, oral cavity, eyes, genital tract, and central nervous system. Systemic disease may also occur, in which the virus may be detectable in the bloodstream. The detection of HSV-1 or HSV-2 DNA from blood specimens may help support the diagnosis of disseminated disease associated with this virus.

Reference Range Information
Performing LocationReference Range
Mayo Clinic ​Laboratories

HERPES SIMPLEX VIRUS (HSV)-1

Negative



HERPES SIMPLEX VIRUS (HSV)-2

Negative


Interpretation

This is a qualitative assay; results are reported either as negative or positive for herpes simplex virus (HSV) type 1 or HSV type 2.

An Indeterminate result means that HSV DNA was detected, but the assay was unable to differentiate between HSV type 1 and HSV type 2. If typing is required, it is recommended that a new sample be collected and tested by an alternate method.

Detection of HSV DNA in clinical specimens supports the clinical diagnosis of infection due to the virus.



Outreach CPTs
CPTModifier
(if needed)
Quantity
DescriptionComments
87529
​2
​Herpes simplex virus, amplified probe technique​
Synonyms/Keywords

​​Herpes Simplex Virus Detection by Real-Time PCR

HSV (Herpes Simplex Virus) by PCR (Polymerase Chain Reaction)

HSV Detection by Real-Time PCR

HSV PCR

LightCycler HSV​


Ordering Applications
Ordering Application
Description
​Cerner
​Herpes Simplex Virus (HSV), Molecular Detection, PCR, Blood (HSVPB)​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/Tube
Acceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

​Whole Blood
​EDTA Lavender Top Tube (LTT)
​1 mL
​0.4 mL
Collection Processing

Send whole blood specimen in original tube. Do not aliquot.

Specimen Stability Information
Specimen TypeTemperature
Time

​Whole Blood


​Refrigerated (preferred)
​7 days
​Frozen
​7 days
Rejection Criteria

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Interference

This test is intended for patients with evidence of disseminated disease due to herpes simplex virus (HSV). For patients with localized (eg, skin, genital) disease, a swab of suspect lesions should be collected and submitted for real-time polymerase chain reaction (PCR) analysis; HSVPV / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies).  A negative result does not eliminate the possibility of HSV infection.  Although the reference value is typically "negative" for this assay, viral shedding may be detected in asymptomatic individuals. This assay is only to be used for patients with a clinical history and symptoms consistent with HSV infection and must be interpreted in the context of the clinical picture.



Useful For

Aiding in the rapid diagnosis of disseminated disease due to herpes simplex virus (HSV)

Qualitative detection of HSV DNA

This test should not be used to screen asymptomatic patients.

​If herpes simplex virus (HSV) is suspected in sources other than blood, order HSVPV / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Varies.

If HSV is suspected in cerebrospinal fluid, order HSVC / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Spinal Fluid.

Reference Range Information
Performing LocationReference Range
Mayo Clinic ​Laboratories

HERPES SIMPLEX VIRUS (HSV)-1

Negative



HERPES SIMPLEX VIRUS (HSV)-2

Negative


Interpretation

This is a qualitative assay; results are reported either as negative or positive for herpes simplex virus (HSV) type 1 or HSV type 2.

An Indeterminate result means that HSV DNA was detected, but the assay was unable to differentiate between HSV type 1 and HSV type 2. If typing is required, it is recommended that a new sample be collected and tested by an alternate method.

Detection of HSV DNA in clinical specimens supports the clinical diagnosis of infection due to the virus.



For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Mayo Clinic Laboratories
​Monday through Saturday
​Same day/1 to 4 days
​Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
Quantity
DescriptionComments
87529
​2
​Herpes simplex virus, amplified probe technique​
For most current information refer to the Marshfield Laboratory online reference manual.