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26475 Maternal Cell Contamination, Molecular Analysis, Varies (MATCC)

Maternal Cell Contamination, Molecular Analysis, Varies (MATCC)
Test Code: MCCSO
Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Useful For

Ruling out the presence of maternal cell contamination within a fetal specimen

Required for all prenatal testing performed in Mayo Clinic Laboratories' Molecular and Biochemical Genetics laboratories

GENETICS TEST INFORMATION: 

**Required in conjunction with molecular and biochemical prenatal testing only.**

Specimen Requirements

Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​When this test is ordered, both a maternal specimen and a prenatal specimen are both required under separate order numbers.
​Maternal Whole Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)
​3 mL
​ ​ ​Prenatal Specimens - submit only 1 of the following specimens: (See Mayo Clinic Laboratories for other acceptable specimens) 
​Cord Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)
​3 mL
Collection Processing Instructions

ORDERING GUIDANCE:

If a prenatal specimen has already been submitted as part of another diagnostic test, a second prenatal specimen is not required. If a prenatal specimen has not yet been submitted, submit only 1 prenatal specimen.

ADDITIONAL TESTING REQUIREMENTS:

A maternal specimen and a prenatal specimen are both required.

-This test must be ordered on both the prenatal and maternal specimens under separate order numbers.

SHIPPING INSTRUCTIONS:

Specimen preferred to arrive within 96 hours of collection.

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.


Prenatal/Proband Specimens

Due to its complexity, consultation with the laboratory is required for all prenatal testing; call 800-533-1710 to speak to a genetic counselor.

Specimen Stability Information

Specimen TypeTemperature
Time
​Maternal Blood ​
​Ambient (preferred)​4 Days
​Refrigerated​4​ Days
​Frozen
​4 Days
​Cord Blood ​​Ambient (preferred)​4 Days
​Refrigerated​4 Days
​Frozen
​4 Days
Rejection Criteria
All specimens will be evaluated by Mayo Clinic Laboratories for test suitability.
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Varies​
​10 to 11 days​Polymerase Chain Reaction (PCR) based comparison of Microsatellite Markers
Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​An interpretive report will be provided.
Interpretation

​An interpretive report will be provided.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​81265​1
​88233​1​Fibroblast Culture for Genetic Test​if appropriate
​88240​1​Fibroblast Culture for Genetic Test​if appropriate
​88235​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​88240​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​81266​Each additional specimen
Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Ordering Applications
Ordering ApplicationDescription
​COM​Maternal Cell Contamination, B (MATCC)
​Cerner​Maternal Cell Contam. (MATCC)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements

Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​When this test is ordered, both a maternal specimen and a prenatal specimen are both required under separate order numbers.
​Maternal Whole Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)
​3 mL
​ ​ ​Prenatal Specimens - submit only 1 of the following specimens: (See Mayo Clinic Laboratories for other acceptable specimens) 
​Cord Blood​EDTA Lavender Top Tube (LTT) or ACD Yellow Top Tube (YTT)
​3 mL
Collection Processing

ORDERING GUIDANCE:

If a prenatal specimen has already been submitted as part of another diagnostic test, a second prenatal specimen is not required. If a prenatal specimen has not yet been submitted, submit only 1 prenatal specimen.

ADDITIONAL TESTING REQUIREMENTS:

A maternal specimen and a prenatal specimen are both required.

-This test must be ordered on both the prenatal and maternal specimens under separate order numbers.

SHIPPING INSTRUCTIONS:

Specimen preferred to arrive within 96 hours of collection.

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.


Prenatal/Proband Specimens

Due to its complexity, consultation with the laboratory is required for all prenatal testing; call 800-533-1710 to speak to a genetic counselor.

Specimen Stability Information

Specimen TypeTemperature
Time
​Maternal Blood ​
​Ambient (preferred)​4 Days
​Refrigerated​4​ Days
​Frozen
​4 Days
​Cord Blood ​​Ambient (preferred)​4 Days
​Refrigerated​4 Days
​Frozen
​4 Days
Rejection Criteria
All specimens will be evaluated by Mayo Clinic Laboratories for test suitability.
Useful For

Ruling out the presence of maternal cell contamination within a fetal specimen

Required for all prenatal testing performed in Mayo Clinic Laboratories' Molecular and Biochemical Genetics laboratories

GENETICS TEST INFORMATION: 

**Required in conjunction with molecular and biochemical prenatal testing only.**

Test Components

For prenatal specimens only: If amniotic fluid (nonconfluent cultured cells) is received, amniotic fluid culture/genetic test will be added and charged separately. If chorionic villus specimen (nonconfluent cultured cells) is received, fibroblast culture for genetic test will be added and charged separately.

If this test is ordered in conjunction with CMAP / Chromosomal Microarray, Prenatal, Amniotic Fluid/Chorionic Villus Sampling or CMAPC / Chromosomal Microarray, Autopsy, Products of Conception, or Stillbirth, and no other molecular testing is ordered, test will be changed to PPAP / Parental Sample Prep for Prenatal Microarray Testing, Blood.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​An interpretive report will be provided.
Interpretation

​An interpretive report will be provided.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Varies​
​10 to 11 days​Polymerase Chain Reaction (PCR) based comparison of Microsatellite Markers
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​81265​1
​88233​1​Fibroblast Culture for Genetic Test​if appropriate
​88240​1​Fibroblast Culture for Genetic Test​if appropriate
​88235​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​88240​1​Amniotic Fluid Culture/Genetic Test​if appropriate
​81266​Each additional specimen
For most current information refer to the Marshfield Laboratory online reference manual.