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26314 Cardiolipin Antibody, IgG

Cardiolipin Antibody, IgG
Test Code: ACLG
Synonyms/Keywords

​Anti-Phospholipid Antibodies, Anticardiolipin Antibodies, Antiphospholipid Antibodies, Cardiolipin, Cardiolipin Antibodies, Antiphospholipid syndrome, APS, systemic lupus erythematosus, SLE

Useful For

​This semi-quantitative test panel detects IgG antibodies to Cardiolipin to aid in the diagnosis of primary Antiphospholipid Syndrome (APS) and those secondary to systemic lupus erythematosus (SLE) or SLE-disorders.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT)​Serum Separator Tube (SST)​1 mL​0.5 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​​Refrigerated​7 days
​Frozen​>7 days
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Heat-inactivated samples
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday, 0700 to 1600​2 to 4 hours​Multiplex Flow Immunoassay/BioRad Bioplex 2200
Test Information

The ACLG test utilizes multiplex flow immunoassay, a methodology that greatly resembles traditional EIA, but permits simultaneous detection and identification of many antibodies in a single tube.

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the venous and/or arterial thrombosis, thrombocytopenia, recurrent fetal loss, and moderate-to-high titers of antiphospholipid (aPL) antibodies, lupus anticoagulant (LA), anti-Cardiolipin (aCL) antibodies, and anti-B2-GP1 antibodies.  A definitive diagnosis of APS requires the presence of at least one clinical manifestation and on positive laboratory result.  Due to the heterogeneous nature of aPL antibodies, combined measurements of ACL and B2GP1 antibodies may provide better sensitivity than either assay alone.

Reference Range Information
Performing LocationReference Range
​Marshfield

ACL IgG GPL U/mL:

Negative <20

Positive ≥20

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86147​1​Cardiolipin Antibodies IgG
Synonyms/Keywords

​Anti-Phospholipid Antibodies, Anticardiolipin Antibodies, Antiphospholipid Antibodies, Cardiolipin, Cardiolipin Antibodies, Antiphospholipid syndrome, APS, systemic lupus erythematosus, SLE

Ordering Applications
Ordering ApplicationDescription
​COM​Cardiolipin Ab, IgG
​Cerner​Cardiolipin Ab, IgG
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Red Top Tube (RTT)​Serum Separator Tube (SST)​1 mL​0.5 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​​Refrigerated​7 days
​Frozen​>7 days
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Heat-inactivated samples
Useful For

​This semi-quantitative test panel detects IgG antibodies to Cardiolipin to aid in the diagnosis of primary Antiphospholipid Syndrome (APS) and those secondary to systemic lupus erythematosus (SLE) or SLE-disorders.

Reference Range Information
Performing LocationReference Range
​Marshfield

ACL IgG GPL U/mL:

Negative <20

Positive ≥20

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield​Monday through Friday, 0700 to 1600​2 to 4 hours​Multiplex Flow Immunoassay/BioRad Bioplex 2200
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86147​1​Cardiolipin Antibodies IgG
For most current information refer to the Marshfield Laboratory online reference manual.