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26297 Myoglobin, Serum (MYGLS)

Myoglobin, Serum (MYGLS)
Test Code: MYGLSSO
Synonyms/Keywords

​Myoglobin, Serum

Useful For

​Assessing muscle damage from any cause

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL
Collection Processing Instructions

​Centrifuge and aliquot serum into plastic vial.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​​Refrigerated (preferred)​14 days
​Frozen​14 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

Elevation is nonspecific for acute myocardial infarction. The test is of no value in this regard in the presence of renal failure, rhabdomyolysis, extensive trauma, acute peripheral vascular occlusion, or after seizures.

Serum levels rise in renal insufficiency.

In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

Results are unreliable in lipemic serum; specimens that cannot be cleared by ultracentrifugation will be rejected.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Sunday​1 to 2 days​Latex Particle-Enhanced Immunoturbidometric Assay
Reference Lab
Test Information

Myoglobin is a heme protein found in smooth and skeletal muscles. Serum myoglobin reflects a balance between intravascular release of myoglobin from muscle and renal clearance.

Previously serum myoglobin had been advocated as a sensitive marker for early acute myocardial injury (eg, acute myocardial infarction: AMI). However, more recent studies indicate that other newer markers (eg, troponin) provide superior diagnostic utility in detecting early myocardial injury.

Elevation of serum myoglobin may occur as a result of muscle trauma, resuscitation, myopathies, AMI, shock, strenuous body activity, or decreased elimination during renal insufficiency. Extreme elevations occur in rhabdomyolysis.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​< or = 90 mcg/L
Interpretation

​Elevated myoglobin levels are seen in conditions of acute muscle injury.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​83874​1
Synonyms/Keywords

​Myoglobin, Serum

Ordering Applications
Ordering ApplicationDescription
​COM​Myoglobin, Serum
​CERNER​Myoglobin, Serum (MYGLS)
​CENTRICITY​Myoglobin, Serum (MYGLS)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL
Collection Processing

​Centrifuge and aliquot serum into plastic vial.

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​​Refrigerated (preferred)​14 days
​Frozen​14 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

Elevation is nonspecific for acute myocardial infarction. The test is of no value in this regard in the presence of renal failure, rhabdomyolysis, extensive trauma, acute peripheral vascular occlusion, or after seizures.

Serum levels rise in renal insufficiency.

In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

Results are unreliable in lipemic serum; specimens that cannot be cleared by ultracentrifugation will be rejected.

Useful For

​Assessing muscle damage from any cause

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​< or = 90 mcg/L
Interpretation

​Elevated myoglobin levels are seen in conditions of acute muscle injury.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Sunday​1 to 2 days​Latex Particle-Enhanced Immunoturbidometric Assay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​83874​1
For most current information refer to the Marshfield Laboratory online reference manual.