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26272 Porphobilinogen, Quantitative, Random, Urine (PBGU)

Porphobilinogen, Quantitative, Random, Urine (PBGU)
Test Code: PBGUSO
Synonyms/Keywords

​Acute Intermittent Porphyria (AIP)
Hereditary Coproporphyria (HCP)
PBG (Porphobilinogen)
Variegate Porphyria (VP)

Useful For

​First-order test for evaluation of a suspected acute porphyria: acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Urine​Urine Container - Amber​Sterile Container​20 mL​15 mL
Collection Processing Instructions

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative necessary but pH must be >5.0.

3. Specimens should be frozen immediately following collection.

**Ship specimen protected from light.**

Specimen Stability Information
Specimen TypeTemperatureTime​Special Container
​Urine ​​Frozen (preferred)​7 days​Light Protected
​Refrigerated​7 days​Light Protected
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Interference

It is recommended that specimen collection occur during the acute phase. Porphobilinogen (PBG) may be normal when the patient is not exhibiting symptoms.

If the specimen is collected after treatment is initiated, the level of PBG excreted may be decreased.

Specimens should be frozen immediately following collection and protected from light. PBG is susceptible to degradation at high temperatures, at pH below 5.0, and on prolonged exposure to light.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​2 days​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​< or =1.3 mcmol/L
Interpretation

​Abnormal results are reported with a detailed interpretation that may include an overview of the results and their significance, a correlation to available clinical information provided with the specimen, differential diagnosis, and recommendations for additional testing when indicated and available, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​84110​1
Synonyms/Keywords

​Acute Intermittent Porphyria (AIP)
Hereditary Coproporphyria (HCP)
PBG (Porphobilinogen)
Variegate Porphyria (VP)

Ordering Applications
Ordering ApplicationDescription
​COM​Porphobilinogen, Quant, R, U
​Cerner​Porphobilinogen Qnt, U (PBGU)
​Centricity​Porphobilinogen Qnt, U (PBGU)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Urine​Urine Container - Amber​Sterile Container​20 mL​15 mL
Collection Processing

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative necessary but pH must be >5.0.

3. Specimens should be frozen immediately following collection.

**Ship specimen protected from light.**

Specimen Stability Information
Specimen TypeTemperatureTime​Special Container
​Urine ​​Frozen (preferred)​7 days​Light Protected
​Refrigerated​7 days​Light Protected
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Interference

It is recommended that specimen collection occur during the acute phase. Porphobilinogen (PBG) may be normal when the patient is not exhibiting symptoms.

If the specimen is collected after treatment is initiated, the level of PBG excreted may be decreased.

Specimens should be frozen immediately following collection and protected from light. PBG is susceptible to degradation at high temperatures, at pH below 5.0, and on prolonged exposure to light.

Useful For

​First-order test for evaluation of a suspected acute porphyria: acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​< or =1.3 mcmol/L
Interpretation

​Abnormal results are reported with a detailed interpretation that may include an overview of the results and their significance, a correlation to available clinical information provided with the specimen, differential diagnosis, and recommendations for additional testing when indicated and available, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​2 days​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​84110​1
For most current information refer to the Marshfield Laboratory online reference manual.