HPV (Human Papillomavirus), HPV E6/E7, GPHPVE6ISH, ISHPVE6E7IISH, ISNEGHPVE6E7ISH, ISRNAHPVE6E7ISH
Stratification of oropharyngeal squamous cell carcinoma.
If additional interpretation or analysis is needed, request PATHC/Pathology Consultation along with this test.
Shipping Instructions: Attach the green pathology address label included in the kit to the outside of the transport container.
A pathology/diagnostic report and a brief history are required.
Mayo Labs suggests supply: Pathology Packaging Kit (T554)
Nonformalin fixed tissue
Nonparaffin embedded tissue
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut fresh.
This assay is intended to identify the presence of human papillomavirus (HPV) E6/E7 transcripts from high-risk genotypes. This test has been shown to be more sensitive than HPV DNA in situ hybridization (ISH). Patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) have shown better disease-specific survival and overall survival when compared to HPV-negative cases of OPSCC. An indication for this test is p16 expression by immunohistochemistry and negative HPV DNA ISH. In this instance, consideration should be given to the possibility of a false-negative HPV DNA ISH result.
This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request PATHC / Pathology Consultation along with this test.