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26186 Volatile Screen, Serum (VLTS)

Volatile Screen, Serum (VLTS)
Test Code: VLTSSO
Synonyms/Keywords

​Acetone
Alcohol
Ethanol
Ethyl Alcohol
ETOH (Ethanol)
Isopropanol
Methanol

Test Components

​This test includes analysis for methanol, ethanol, isopropanol, and acetone. 

Useful For

​Detection and quantitation of acetone, methanol, isopropanol, and ethanol in serum

Quantification of the concentration of ethanol in serum correlates with degree of intoxication

Evaluation of toxicity to the measured volatile substances

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​Full Tube​0.5 mL
Collection Processing Instructions

If collecting in a Serum Separator Tube:​

1. Arm must be cleansed with water only.

2. Avoid exposure of specimen to atmosphere.

3. Do not aliquot.

 

If collecting in a Red Top Tube: 

1. Arm must be cleansed with water only.

2. Avoid exposure of specimen to atmosphere.

3. Centrifuge specimen within 2 hours of draw and send serum aliquot to laboratory refrigerated.

*This test is only valid to be ordered from MCHS hospital location/branches which includes the following branches: MMC-Marshfield, MMC-Eau Claire, MMC-Park Falls, MMC-Ladysmith, MMC-Minocqua, MMC-Neillsville, MMC-Rice Lake, MMC-Weston

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​14 days
​Frozen28 days
​Ambient​24 hours
Interference

​No significant cautionary statements.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​1 day​Headspace Gas Chromatography-Flame Ionization Detector (HSGC-FID)
Reference Lab
Test Information

Volatile substances in the blood include ethanol, methanol, isopropanol, and acetone. Methanol and isopropanol are highly toxic; toxicity results from ingestion (exogenous). Acetone is generally elevated in metabolic conditions such as diabetic ketoacidosis (endogenous). It also is a metabolite of isopropanol.

Ethanol is the single most important substance of abuse in the United States. It is the active agent in beer, wine, vodka, whiskey, rum, and other liquors. Ethanol acts on cerebral function as a depressant similar to general anesthetics. This depression causes most of the typical symptoms such as impaired thought, clouded judgment, and changed behavior. As the level of alcohol increases, the degree of impairment progressively increases.

On average, the serum or plasma concentration of the alcohols is 1.2-fold higher than blood concentration. For example, the serum or plasma would contain approximately 0.10 g/dL of ethanol in a blood specimen that contains 0.08 g/dL ethanol. Due to potential variations in the serum to whole blood ratio, serum should not be used in a medico-legal context. However, in the context of medical/clinical assessment, serum or plasma may be submitted for analysis.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

METHANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

ETHANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =400 mg/dL

ISOPROPANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

ACETONE

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

 

Interpretation

​Methanol:

The presence of methanol indicates exposure which may result in intoxication, central nervous system (CNS) depression, and metabolic acidosis. Ingestion of methanol can be fatal if patients do not receive immediate medical treatment.

Ethanol:

The presence of ethanol indicates exposure which may result in intoxication, CNS depression, and metabolic acidosis.

Isopropanol:

The presence of isopropanol indicates exposure which may result in intoxication and CNS depression. Ingestion of isopropanol can be fatal if patients do not receive immediate medical treatment.

Acetone:

The presence of acetone may indicate exposure to acetone; it is also a metabolite of isopropanol and may be detected during ketoacidosis.

Outreach CPTs

​CPT

Modifier     
(if needed)

QuantityDescriptionComments
​80320​1​Screen

 

Synonyms/Keywords

​Acetone
Alcohol
Ethanol
Ethyl Alcohol
ETOH (Ethanol)
Isopropanol
Methanol

Test Components

​This test includes analysis for methanol, ethanol, isopropanol, and acetone. 

Ordering Applications
Ordering ApplicationDescription
Cerner​Volatile Screen, Serum (VLTS)
​Centricity​Volatile Screen, Serum (VLTS)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​Full Tube​0.5 mL
Collection Processing

If collecting in a Serum Separator Tube:​

1. Arm must be cleansed with water only.

2. Avoid exposure of specimen to atmosphere.

3. Do not aliquot.

 

If collecting in a Red Top Tube: 

1. Arm must be cleansed with water only.

2. Avoid exposure of specimen to atmosphere.

3. Centrifuge specimen within 2 hours of draw and send serum aliquot to laboratory refrigerated.

*This test is only valid to be ordered from MCHS hospital location/branches which includes the following branches: MMC-Marshfield, MMC-Eau Claire, MMC-Park Falls, MMC-Ladysmith, MMC-Minocqua, MMC-Neillsville, MMC-Rice Lake, MMC-Weston

Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​14 days
​Frozen28 days
​Ambient​24 hours
Interference

​No significant cautionary statements.

Useful For

​Detection and quantitation of acetone, methanol, isopropanol, and ethanol in serum

Quantification of the concentration of ethanol in serum correlates with degree of intoxication

Evaluation of toxicity to the measured volatile substances

Test Components

​This test includes analysis for methanol, ethanol, isopropanol, and acetone. 

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

METHANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

ETHANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =400 mg/dL

ISOPROPANOL

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

ACETONE

Not detected (Positive results are quantitated.)

Toxic concentration: > or =10 mg/dL

 

Interpretation

​Methanol:

The presence of methanol indicates exposure which may result in intoxication, central nervous system (CNS) depression, and metabolic acidosis. Ingestion of methanol can be fatal if patients do not receive immediate medical treatment.

Ethanol:

The presence of ethanol indicates exposure which may result in intoxication, CNS depression, and metabolic acidosis.

Isopropanol:

The presence of isopropanol indicates exposure which may result in intoxication and CNS depression. Ingestion of isopropanol can be fatal if patients do not receive immediate medical treatment.

Acetone:

The presence of acetone may indicate exposure to acetone; it is also a metabolite of isopropanol and may be detected during ketoacidosis.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Friday​1 day​Headspace Gas Chromatography-Flame Ionization Detector (HSGC-FID)
Reference Lab
For billing questions, see Contacts
Outreach CPTs

​CPT

Modifier     
(if needed)

QuantityDescriptionComments
​80320​1​Screen

 

For most current information refer to the Marshfield Laboratory online reference manual.