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26160 Anti-DNase B Titer, Serum (ADNAS)

Anti-DNase B Titer, Serum (ADNAS)
Test Code: ADNASSO
Synonyms/Keywords

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Useful For

Demonstration of acute or recent streptococcal infection using anti-DNase B titer.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Yes-preferred​Serum​Red Top Tube (RTT)​1 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum​Refrigerate (preferred)​28 days
​Frozen​28 days
​Ambient​7 days
Rejection Criteria
Grossly Lipemic
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Saturday​2 days​Siemens Nephelometer II method
Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

​<5 years: <=250 U/ml

5-17 years <=375 U/ml

>=18 years: <=300 U/ml

Interpretation

Elevated values are consistent with an antecedent infection by group A streptococci. Although the antistreptolysin O (ASO) test is quite reliable, performing the anti-DNase is justified for 2 primary reasons. First, the ASO response is not universal. Elevated ASO titers are found in the sera of about 85% of individuals with rheumatic fever; ASO titers remain normal in about 15% of individuals with the disease. The same holds true for other streptococcal antibody tests: a significant portion of individuals with normal antibody titers for 1 test will have elevated antibody titers for another test. Thus, the percentage of false­ negatives can be reduced by performing 2 or more antibody tests. Second, skin infections, in contrast to throat infections, are associated with a poor ASO response. Patients with acute glomerulonephritis following skin infection (post-impetigo) have an attenuated immune response to streptolysin 0. For such patients, performance of an alternative streptococcal antibody test, such as this assay, is recommended.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86215​1
Synonyms/Keywords

​​

Ordering Applications
Ordering ApplicationDescription
​Cerner​Anti-DNase B Titer, Serum (ADNAS)
​COM​Anti-DNase B Titer, Serum (ADNAS)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Yes-preferred​Serum​Red Top Tube (RTT)​1 mL​0.5 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum​Refrigerate (preferred)​28 days
​Frozen​28 days
​Ambient​7 days
Rejection Criteria
Grossly Lipemic
Useful For

Demonstration of acute or recent streptococcal infection using anti-DNase B titer.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories

​<5 years: <=250 U/ml

5-17 years <=375 U/ml

>=18 years: <=300 U/ml

Interpretation

Elevated values are consistent with an antecedent infection by group A streptococci. Although the antistreptolysin O (ASO) test is quite reliable, performing the anti-DNase is justified for 2 primary reasons. First, the ASO response is not universal. Elevated ASO titers are found in the sera of about 85% of individuals with rheumatic fever; ASO titers remain normal in about 15% of individuals with the disease. The same holds true for other streptococcal antibody tests: a significant portion of individuals with normal antibody titers for 1 test will have elevated antibody titers for another test. Thus, the percentage of false­ negatives can be reduced by performing 2 or more antibody tests. Second, skin infections, in contrast to throat infections, are associated with a poor ASO response. Patients with acute glomerulonephritis following skin infection (post-impetigo) have an attenuated immune response to streptolysin 0. For such patients, performance of an alternative streptococcal antibody test, such as this assay, is recommended.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday through Saturday​2 days​Siemens Nephelometer II method
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86215​1
For most current information refer to the Marshfield Laboratory online reference manual.