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26144 Copeptin proAVP, Plasma (CPAVP)

Copeptin proAVP, Plasma (CPAVP)
Test Code: CPAVPSO
Synonyms/Keywords

The investigation of the differential diagnosis of patients with water balance disorders, including Diabetes Insipidus (DI) in conjunction with osmolality and hydration status.

May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

​Yes

8 hours (no liquids, including water)

​Plasma ​EDTA Lavender Top Tube (LTT) ​0.5 mL ​0.3 mL
Collection Processing Instructions
Collect in an EDTA lavender top tube, submit sample in a plastic screw-top aliquot tube.
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​ ​Refrigerate ​7 days
​Frozen ​30 days
Interference
Sepsis, Severe Sepsis, Septic Shock, Lower Respiratory Tract Infections and COPD, Cardiovascular Diseases, i.e. Chronic Heart Failure may increase copeptin concentrations. AVP receptor antagonist therapies and other diseases in which AVP has been shown to play an important pathophysiologic role may also increase copeptin concentration. In some cases bronchial carcinoma may lead to ectopic copeptin secretion. Mixed forms of DI can exist, and both central and peripheral DI may be incomplete, complicating the interpretation of results. Some patients who have been exposed to animal antigens, either in the environment or as part of treatment or imaging procedures, may have circulating anti-animal antibodies present. These antibodies may interfere with the assay reagents to produce unreliable results.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Saturday ​1-2 days ​Immunoflourescent Assay
Reference Lab
Test Information
Copeptin (also known as Copeptin proAVP or Copeptin AVP) and arginine vasopressin (AVP) are derived from the same precursor peptide. Copeptin has been proposed as a more stable, potentially superior, surrogate marker of AVP in the assessment of water balance disorders. Both copeptin and AVP are responsive to osmotic stimuli and increase in response to water deprivation. The determination of the underlying disease pathology in patients with polyuria and altered plasma osmolality is often difficult. Polyuria can be related to insufficient AVP (central diabetes insipidus), reduced sensitivity to AVP (nephrogenic diabetes insipidus), or excessive water intake. Measurement of plasma copeptin concentration has been shown to be useful in the investigation of these AVP-related disorders.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories Non-water deprived, non-fasting adults: <13.1 pmol/L.
 
Water deprived, fasting adults: <15.2 pmol/L.
 
Non-water deprived, non-fasting pediatric patients:<14.5 pmol/L
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​84588 ​1
Synonyms/Keywords

The investigation of the differential diagnosis of patients with water balance disorders, including Diabetes Insipidus (DI) in conjunction with osmolality and hydration status.

May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers.

Ordering Applications
Ordering Application Description
​Centricity ​Copeptin proAVP, Plasma (CPAVP)
​Cerner ​Copeptin proAVP, Plasma (CPAVP)
​COM ​Copeptin proAVP, Plasma (CPAVP)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

​Yes

8 hours (no liquids, including water)

​Plasma ​EDTA Lavender Top Tube (LTT) ​0.5 mL ​0.3 mL
Collection Processing
Collect in an EDTA lavender top tube, submit sample in a plastic screw-top aliquot tube.
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​ ​Refrigerate ​7 days
​Frozen ​30 days
Interference
Sepsis, Severe Sepsis, Septic Shock, Lower Respiratory Tract Infections and COPD, Cardiovascular Diseases, i.e. Chronic Heart Failure may increase copeptin concentrations. AVP receptor antagonist therapies and other diseases in which AVP has been shown to play an important pathophysiologic role may also increase copeptin concentration. In some cases bronchial carcinoma may lead to ectopic copeptin secretion. Mixed forms of DI can exist, and both central and peripheral DI may be incomplete, complicating the interpretation of results. Some patients who have been exposed to animal antigens, either in the environment or as part of treatment or imaging procedures, may have circulating anti-animal antibodies present. These antibodies may interfere with the assay reagents to produce unreliable results.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories Non-water deprived, non-fasting adults: <13.1 pmol/L.
 
Water deprived, fasting adults: <15.2 pmol/L.
 
Non-water deprived, non-fasting pediatric patients:<14.5 pmol/L
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Saturday ​1-2 days ​Immunoflourescent Assay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​84588 ​1
For most current information refer to the Marshfield Laboratory online reference manual.