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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hepatitis C Genotype (HCVG)
Test Code: HCVGSO
Synonyms/Keywords
HCV Genotype, S; HCVG; HCV Genotyping
Useful For

Determining hepatitis C virus genotype (1 to 5) to guide antiviral therapy in patients with chronic hepatitis C. Differentiating between hepatitis C virus subtypes 1a and 1b

Caution: This assay should not be used as a screening test for hepatitis C virus (HCV) infection. It should be performed only on specimens obtained from patients confirmed to have HCV RNA levels in serum of 500 IU/mL or higher.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Serum Separator Tube (SST)/Aliquot Tube/Polypropylene Vial ​5 mL ​1.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum (SST) ​ ​Frozen (preferred) ​42 days
​Refrigerate ​72 hours
Rejection Criteria
Heparized specimen
​Red Top Tube
​Plasma
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Friday

​Monday through Thursday - 1 day

Friday - 3 days

​The Abbott RealTime HCV Genotype II Assay 
Reference Lab
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Undetected
Interpretation

An "Undetected" result indicates the absence of detectable hepatitis C virus (HCV) RNA in the specimen.

An "Indeterminate" result may be due to 1 or more of the following causes: 1) low HCV RNA level (ie,<500 IU/mL), 2) HCV genotype 6, 3) probe reactivity with multiple HCV genotypes, or 4) variation in patient's HCV target sequences with mismatches to PCR primers and/or probes. Specimens generating indeterminate results with this assay will be automatically evaluated with the subsequent test HCVGR / Hepatitis C Virus Genotype Resolution, Serum.

An HCV genotype result of "1" without a subtype result may be due to 1 or more of the following causes: 1) low HCV RNA level (ie, <500 IU/mL), 2) probe reactivity with multiple genotype 1 subtypes, 3) variation in HCV genotype 1 target sequence, or 4) misclassification of some true genotype 6 strains. This assay is able to differentiate between HCV subtypes 1a and 1b. However, subtypes are not reported for HCV genotypes 2 to 5 due to limitations of the current genotyping assay in accurately differentiating the various subtypes of these genotypes.

Results with multiple or mixed HCV genotypes (eg, 1, 5; 1a, 2; or 3, 5) may be due to mixed genotype infection or assay probe cross-reactivity. Only those specimens with multiple or mixed genotype results containing genotype 1 but no subtype will be automatically evaluated with the subsequent test HCVGR / Hepatitis C Virus Genotype Resolution, Serum.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​87902 ​1
Synonyms/Keywords
HCV Genotype, S; HCVG; HCV Genotyping
Ordering Applications
Ordering Application Description
​Centricity ​Hepatitis C Genotype (HCVG)
​Cerner ​Hepatitis C Genotype (HCVG)
​COM ​Hepatitis C Genotype (HCVG)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Serum Separator Tube (SST)/Aliquot Tube/Polypropylene Vial ​5 mL ​1.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum (SST) ​ ​Frozen (preferred) ​42 days
​Refrigerate ​72 hours
Rejection Criteria
Heparized specimen
​Red Top Tube
​Plasma
Useful For

Determining hepatitis C virus genotype (1 to 5) to guide antiviral therapy in patients with chronic hepatitis C. Differentiating between hepatitis C virus subtypes 1a and 1b

Caution: This assay should not be used as a screening test for hepatitis C virus (HCV) infection. It should be performed only on specimens obtained from patients confirmed to have HCV RNA levels in serum of 500 IU/mL or higher.

Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Undetected
Interpretation

An "Undetected" result indicates the absence of detectable hepatitis C virus (HCV) RNA in the specimen.

An "Indeterminate" result may be due to 1 or more of the following causes: 1) low HCV RNA level (ie,<500 IU/mL), 2) HCV genotype 6, 3) probe reactivity with multiple HCV genotypes, or 4) variation in patient's HCV target sequences with mismatches to PCR primers and/or probes. Specimens generating indeterminate results with this assay will be automatically evaluated with the subsequent test HCVGR / Hepatitis C Virus Genotype Resolution, Serum.

An HCV genotype result of "1" without a subtype result may be due to 1 or more of the following causes: 1) low HCV RNA level (ie, <500 IU/mL), 2) probe reactivity with multiple genotype 1 subtypes, 3) variation in HCV genotype 1 target sequence, or 4) misclassification of some true genotype 6 strains. This assay is able to differentiate between HCV subtypes 1a and 1b. However, subtypes are not reported for HCV genotypes 2 to 5 due to limitations of the current genotyping assay in accurately differentiating the various subtypes of these genotypes.

Results with multiple or mixed HCV genotypes (eg, 1, 5; 1a, 2; or 3, 5) may be due to mixed genotype infection or assay probe cross-reactivity. Only those specimens with multiple or mixed genotype results containing genotype 1 but no subtype will be automatically evaluated with the subsequent test HCVGR / Hepatitis C Virus Genotype Resolution, Serum.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Friday

​Monday through Thursday - 1 day

Friday - 3 days

​The Abbott RealTime HCV Genotype II Assay 
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​87902 ​1
For most current information refer to the Marshfield Laboratory online reference manual.