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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Parvovirus B19 Antibodies, IgG and IgM, Serum (PARVS)
Test Code: PARVSSO
Synonyms/Keywords

B19

Erythrovirus B19

Fifth Disease

Human Parvovirus

Test Components
Parvovirus B19 IgG & IgM Antibodies with Interpretation
Useful For

This assay may be used to determine serostatus of patients at risk for infection with parvovirus B19.

Results may be used, along with clinical evaluation and additional laboratory findings, to determine recent or past infection status with parvovirus B19.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.5 mL
Collection Processing Instructions
Collect in appropriate specimen container and aliquot into a sterile plastic vial for specimen submission.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate (preferred) ​14 days
​Frozen ​14 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

Specimens drawn prior to seroconversion may yield negative IgM and IgG antibody results, while specimens drawn after IgM antibody levels have begun to decline may yield negative IgM antibody results. The results of a single assay or a combination of IgM and IgG EIAs should not preclude additional testing. Follow-up testing of convalescent samples may be beneficial to establish infection status.

The continued presence or absence of antibodies cannot be used to determine the success or failure of therapy.

Test results of specimens from immunocompromised patients may be difficult to interpret. Testing should not be performed as a screening procedure for the general population.

Testing should only be done when clinical evidence suggests the diagnosis of parvovirus B19-associated disease.

The performance of this test has not been established on neonates and immunocompromised patients.

Specimens containing antinuclear antibodies may produce equivocal or positive test results in the IgM assay.

Epstein-Barr virus-positive specimens may produce positive or equivocal test results in the IgM assay.

Assay performance characteristics have not been established for matrices other than serum.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Friday ​1-3 days ​Enzyme Immunoassay (EIA)
Test Information

Parvovirus B19 may result in an asymptomatic infection or produce a wide spectrum of disease ranging from erythema infections (slapped cheek syndrome or fifth disease) in children to arthropathy, severe anemia, and systemic manifestations involving the central nervous system, heart, and liver depending on the immune competence of the host.(2,3) Infection with parvovirus B19 in pregnant women may cause hydrops fetalis, congenital anemia, abortion, or stillbirth of the fetus.(4) Parvovirus B19 is also the causative agent of persistent anemia usually, but not exclusively, in immunocompromised patients, transplant patients, and infants.

Most acute infections with parvovirus B19 are diagnosed in the laboratory by serologically detecting IgG and IgM class antibodies with enzyme-linked immunosorbent assay testing.

Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories

​IgG: Negative

IgM: Negative

Interpretation
Parvovirus B19 IgM
Parvovirus B19 IgG
Interpretation
Negative
Negative
Implies no past infection or exposure to parvovirus B19. Patient may be susceptible to parvovirus B19 infection
Negative
Positive
Implies past exposure/infection and minimal risk of repeat parvovirus B19 infection
Equivocal
Positive or negative
May indicate current or recent parvovirus B19 infection. Recommendation to test a new convalescent specimen collected in 1 to 2 weeks
Positive
Positive
Suggests current or recent parvovirus B19 infection
Positive
Negative or equivocal
Suggests current or recent parvovirus B19 infection. Recommendation to test a new convalescent specimen collected in 1 to 2 weeks.
 
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86747 ​2
Synonyms/Keywords

B19

Erythrovirus B19

Fifth Disease

Human Parvovirus

Test Components
Parvovirus B19 IgG & IgM Antibodies with Interpretation
Ordering Applications
Ordering Application Description
​Centricity ​Parvovirus B19 Abs, IgG and IgM, Serum (PARVS)
​Cerner ​Parvovirus B19 Abs, IgG and IgM, Serum (PARVS)
​COM ​Parvovirus B19 Abs, IgG and IgM, Serum (PARVS)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.5 mL
Collection Processing Instructions
Collect in appropriate specimen container and aliquot into a sterile plastic vial for specimen submission.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate (preferred) ​14 days
​Frozen ​14 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

Specimens drawn prior to seroconversion may yield negative IgM and IgG antibody results, while specimens drawn after IgM antibody levels have begun to decline may yield negative IgM antibody results. The results of a single assay or a combination of IgM and IgG EIAs should not preclude additional testing. Follow-up testing of convalescent samples may be beneficial to establish infection status.

The continued presence or absence of antibodies cannot be used to determine the success or failure of therapy.

Test results of specimens from immunocompromised patients may be difficult to interpret. Testing should not be performed as a screening procedure for the general population.

Testing should only be done when clinical evidence suggests the diagnosis of parvovirus B19-associated disease.

The performance of this test has not been established on neonates and immunocompromised patients.

Specimens containing antinuclear antibodies may produce equivocal or positive test results in the IgM assay.

Epstein-Barr virus-positive specimens may produce positive or equivocal test results in the IgM assay.

Assay performance characteristics have not been established for matrices other than serum.

Useful For

This assay may be used to determine serostatus of patients at risk for infection with parvovirus B19.

Results may be used, along with clinical evaluation and additional laboratory findings, to determine recent or past infection status with parvovirus B19.

Test Information

Parvovirus B19 may result in an asymptomatic infection or produce a wide spectrum of disease ranging from erythema infections (slapped cheek syndrome or fifth disease) in children to arthropathy, severe anemia, and systemic manifestations involving the central nervous system, heart, and liver depending on the immune competence of the host.(2,3) Infection with parvovirus B19 in pregnant women may cause hydrops fetalis, congenital anemia, abortion, or stillbirth of the fetus.(4) Parvovirus B19 is also the causative agent of persistent anemia usually, but not exclusively, in immunocompromised patients, transplant patients, and infants.

Most acute infections with parvovirus B19 are diagnosed in the laboratory by serologically detecting IgG and IgM class antibodies with enzyme-linked immunosorbent assay testing.

Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories

​IgG: Negative

IgM: Negative

Interpretation
Parvovirus B19 IgM
Parvovirus B19 IgG
Interpretation
Negative
Negative
Implies no past infection or exposure to parvovirus B19. Patient may be susceptible to parvovirus B19 infection
Negative
Positive
Implies past exposure/infection and minimal risk of repeat parvovirus B19 infection
Equivocal
Positive or negative
May indicate current or recent parvovirus B19 infection. Recommendation to test a new convalescent specimen collected in 1 to 2 weeks
Positive
Positive
Suggests current or recent parvovirus B19 infection
Positive
Negative or equivocal
Suggests current or recent parvovirus B19 infection. Recommendation to test a new convalescent specimen collected in 1 to 2 weeks.
 
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Friday ​1-3 days ​Enzyme Immunoassay (EIA)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86747 ​2
For most current information refer to the Marshfield Laboratory online reference manual.