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26055 Granulocyte Antibodies, Serum (LAGGT)

Granulocyte Antibodies, Serum (LAGGT)
Test Code: LAGGTSO
Synonyms/Keywords
Anti-Leukocyte Antibodies
Anti-Neutrophil
Antigranulocyte Antibodies
Granulocyte Ab
Granulocyte Binding IgG
Leukoagglutinin
Neutrophil Antibodies
Anti-Leukocyte Ab
Useful For

The work-up of individuals having febrile, nonhemolytic transfusion reactions.

The detection of individuals with autoimmune neutropenia.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Red Top Tube ​ ​1.5 mL ​0.3 mL ​
Collection Processing Instructions
Only pretransfusion reaction specimen is acceptable.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​30 days
​Ambient ​7 days
​Frozen ​365 days
Rejection Criteria
Serum gel tube
Interference

​Not useful for diagnosis of neutropenia caused by marrow suppression by drugs or tumors

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday, Wednesday, Friday ​7-15 days Indirect Immunofluorescence
Reference Lab
Mayo Clinic Laboratories
Test Information

​Granulocyte antibodies are induced by pregnancy or prior transfusion and are associated with febrile, nonhemolytic transfusion reactions. Patients who have been immunized by previous transfusions, pregnancies, or allografts frequently experience febrile, nonhemolytic transfusion reactions which must be distinguished from hemolysis before further transfusions can be safely administered. Granulocyte antibodies may also be present in autoimmune neutropenia.

Reference Range Information
See Report
Interpretation

​A positive result in an individual being worked up for a febrile transfusion reaction indicates the need for leukocyte-poor (filtered) red blood cells.

This test cannot distinguish between allo- and autoantibodies

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86021 ​ ​1 ​ ​
Synonyms/Keywords
Anti-Leukocyte Antibodies
Anti-Neutrophil
Antigranulocyte Antibodies
Granulocyte Ab
Granulocyte Binding IgG
Leukoagglutinin
Neutrophil Antibodies
Anti-Leukocyte Ab
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Red Top Tube ​ ​1.5 mL ​0.3 mL ​
Collection Processing
Only pretransfusion reaction specimen is acceptable.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​30 days
​Ambient ​7 days
​Frozen ​365 days
Rejection Criteria
Serum gel tube
Interference

​Not useful for diagnosis of neutropenia caused by marrow suppression by drugs or tumors

Useful For

The work-up of individuals having febrile, nonhemolytic transfusion reactions.

The detection of individuals with autoimmune neutropenia.

Reference Range Information
See Report
Interpretation

​A positive result in an individual being worked up for a febrile transfusion reaction indicates the need for leukocyte-poor (filtered) red blood cells.

This test cannot distinguish between allo- and autoantibodies

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday, Wednesday, Friday ​7-15 days Indirect Immunofluorescence
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86021 ​ ​1 ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.