Evaluating patients suspected of having systemic sclerosis, when used in conjunction with centromere and Scl70 antibodies.
Providing diagnostic and prognostic information in patients with systemic sclerosis.
A positive result indicates the presence of measurable IgG antibodies to RNA polymerase III, but does not unequivocally establish the diagnosis of systemic sclerosis or other autoimmune disease.
The level of RNA polymerase III autoantibodies does not indicate the severity of disease in patients with systemic sclerosis.
The presence of immune complexes or other immunoglobulin aggregates in the patient specimen may cause an increased level of nonspecific binding and produce false-positive results with this assay.
A positive result supports a possible diagnosis of systemic sclerosis. This autoantibody is strongly associated with diffuse cutaneous scleroderma and with an increased risk of acute renal crisis.
A negative result indicates no detectable IgG antibodies to RNA polymerase III, but does not rule out the possibility of systemic sclerosis (11%-23% sensitivity).