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26023 Creatine Disorders Panel, Urine (CRDPU)

Creatine Disorders Panel, Urine (CRDPU)
Test Code: CRDPUSO
Synonyms/Keywords

AGAT (Arginine:Glycine Amidinotransferase) Deficiency, Arginine:Glycine Amidinotransferase Deficiency (AGAT), CrT1 defect, GAMT (Guanidinoacetate Methyltransferase) Deficiency, Guanidinoacetate Methyltransferase (GAMT) Deficiency, Guanidinoacetate, Guanidinoacetic acid, Creatine urine, Creatinine urine, Creatine/creatinine ratio urine, Creatine disorders

Creatine Disorders Panel, Random, Urine

U CRDPUSO

 

Useful For
Evaluation of patients with a clinical suspicion of inborn errors of creatine metabolism including arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter (SLC6A8) defect.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine, Random ​Sterile Container ​ ​1 mL ​0.5 mL ​
Collection Processing Instructions

1. Collect a random urine specimen.

2. Immediately freeze specimen.

3. If possible, do not send other tests ordered on same vial of urine. In doing so, the other tests may have increased turnaround time due to the strict frozen criteria of this assay.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Frozen ​29 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Interference
Correct specimen collection and handling are crucial to achieve reliable results.
Creatine supplementation will cause falsely elevated results.
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday ​7 to 18 days ​Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Males
Age
Creatinine (nmol/mL)
Guanidinoacetate (nmol/mL)
Creatine (nmol/mL)
Creatine/
Creatinine
< or =31 days
430-5240
9-210
12-2930
0.02-0.93
32 days-23 months
313-9040
16-860
18-10490
0.02-2.49
2-4 years
1140-12820
90-1260
200-9210
0.04-1.75
5-18 years
1190-25270
40-1190
60-9530
0.01-0.96
>18 years (male)
3854-23340
30-710
7-470
0.00-0.04
 
Females
Age
Creatinine (nmol/mL)
Guanidinoacetate (nmol/mL)
Creatine (nmol/mL)
Creatine/
Creatinine
< or =31 days
430-5240
9-210
12-2930
0.02-0.93
32 days-23 months
313-9040
16-860
18-10490
0.02-2.49
2-4 years
1140-12820
90-1260
200-9210
0.04-1.75
5-18 years
1190-25270
40-1190
60-9530
0.01-0.96
>18 years
1540-18050
30-760
5-2810
0.00-0.46
Interpretation
Reports include concentrations of guanidinoacetate, creatine, and creatinine, and a calculated creatine:creatinine ratio. When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given. This interpretation includes an overview of the results and their significance, a correlation to available clinical information, elements of differential diagnosis, and recommendations for additional biochemical testing.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82540 ​ ​1 ​Creatine ​
​82570 ​ ​1 ​Creatinine ​
​82542 ​ ​1 ​Guanidinoacetate ​
Synonyms/Keywords

AGAT (Arginine:Glycine Amidinotransferase) Deficiency, Arginine:Glycine Amidinotransferase Deficiency (AGAT), CrT1 defect, GAMT (Guanidinoacetate Methyltransferase) Deficiency, Guanidinoacetate Methyltransferase (GAMT) Deficiency, Guanidinoacetate, Guanidinoacetic acid, Creatine urine, Creatinine urine, Creatine/creatinine ratio urine, Creatine disorders

Creatine Disorders Panel, Random, Urine

U CRDPUSO

 

Ordering Applications
Ordering Application Description
​COM Creatine Disorders Panel, Urine (CRDPU)
​Cerner ​Creatine Disorders Panel, Urine (CRDPU)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine, Random ​Sterile Container ​ ​1 mL ​0.5 mL ​
Collection Processing

1. Collect a random urine specimen.

2. Immediately freeze specimen.

3. If possible, do not send other tests ordered on same vial of urine. In doing so, the other tests may have increased turnaround time due to the strict frozen criteria of this assay.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Frozen ​29 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Interference
Correct specimen collection and handling are crucial to achieve reliable results.
Creatine supplementation will cause falsely elevated results.
Useful For
Evaluation of patients with a clinical suspicion of inborn errors of creatine metabolism including arginine:glycine amidinotransferase deficiency, guanidinoacetate methyltransferase deficiency, and creatine transporter (SLC6A8) defect.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​Males
Age
Creatinine (nmol/mL)
Guanidinoacetate (nmol/mL)
Creatine (nmol/mL)
Creatine/
Creatinine
< or =31 days
430-5240
9-210
12-2930
0.02-0.93
32 days-23 months
313-9040
16-860
18-10490
0.02-2.49
2-4 years
1140-12820
90-1260
200-9210
0.04-1.75
5-18 years
1190-25270
40-1190
60-9530
0.01-0.96
>18 years (male)
3854-23340
30-710
7-470
0.00-0.04
 
Females
Age
Creatinine (nmol/mL)
Guanidinoacetate (nmol/mL)
Creatine (nmol/mL)
Creatine/
Creatinine
< or =31 days
430-5240
9-210
12-2930
0.02-0.93
32 days-23 months
313-9040
16-860
18-10490
0.02-2.49
2-4 years
1140-12820
90-1260
200-9210
0.04-1.75
5-18 years
1190-25270
40-1190
60-9530
0.01-0.96
>18 years
1540-18050
30-760
5-2810
0.00-0.46
Interpretation
Reports include concentrations of guanidinoacetate, creatine, and creatinine, and a calculated creatine:creatinine ratio. When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given. This interpretation includes an overview of the results and their significance, a correlation to available clinical information, elements of differential diagnosis, and recommendations for additional biochemical testing.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday ​7 to 18 days ​Liquid Chromatography-Tandem Mass Spectometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82540 ​ ​1 ​Creatine ​
​82570 ​ ​1 ​Creatinine ​
​82542 ​ ​1 ​Guanidinoacetate ​
For most current information refer to the Marshfield Laboratory online reference manual.