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26010 Everolimus, Blood (EVROL)

Everolimus, Blood (EVROL)
Test Code: EVROLSO
Synonyms/Keywords
​Afinitor
Evero
Zortress
Useful For
Management of everolimus immunosuppression in solid organ transplant.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA ​EDTA Lavender Top Tube (LTT) ​ ​3 mL ​1 mL ​
Collection Processing Instructions

Draw blood immediately before next scheduled dose. Do not centrifuge. Send specimen in original tube.

Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.  

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood EDTA ​ ​ ​Refrigerated (preferred) ​28 days
​Frozen ​28 days
​Ambient ​7 days
Interference

​Therapeutic targets vary by transplant site and institution protocol. Established ranges refer to trough (predose) concentrations.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Sunday ​2 days Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​

3-8 ng/mL

Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Interpretation

Therapeutic targets vary by transplant site and institution protocol. Heart and kidney transplant guidelines suggest a therapeutic range of 3 to 8 ng/mL.

Measurement of drug concentrations in oncology chemotherapy is less common, thus no therapeutic range is established for this application.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80169 ​ ​1 ​ ​
Synonyms/Keywords
​Afinitor
Evero
Zortress
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA ​EDTA Lavender Top Tube (LTT) ​ ​3 mL ​1 mL ​
Collection Processing

Draw blood immediately before next scheduled dose. Do not centrifuge. Send specimen in original tube.

Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.  

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood EDTA ​ ​ ​Refrigerated (preferred) ​28 days
​Frozen ​28 days
​Ambient ​7 days
Interference

​Therapeutic targets vary by transplant site and institution protocol. Established ranges refer to trough (predose) concentrations.

Useful For
Management of everolimus immunosuppression in solid organ transplant.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​

3-8 ng/mL

Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Interpretation

Therapeutic targets vary by transplant site and institution protocol. Heart and kidney transplant guidelines suggest a therapeutic range of 3 to 8 ng/mL.

Measurement of drug concentrations in oncology chemotherapy is less common, thus no therapeutic range is established for this application.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday through Sunday ​2 days Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80169 ​ ​1 ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.