Draw blood immediately before next scheduled dose. Do not centrifuge. Send specimen in original tube.
Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.
Therapeutic targets vary by transplant site and institution protocol. Established ranges refer to trough (predose) concentrations.
Target steady-state trough concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time post-transplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.
Therapeutic targets vary by transplant site and institution protocol. Heart and kidney transplant guidelines suggest a therapeutic range of 3 to 8 ng/mL.
Measurement of drug concentrations in oncology chemotherapy is less common, thus no therapeutic range is established for this application.