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25679 Procollagen I Intact N-Terminal, Serum (PINP)

Procollagen I Intact N-Terminal, Serum (PINP)
Test Code: PINPSO
Useful For
​An aid in monitoring antiresorptive and anabolic therapy in patients with osteoporosis
 
An adjunct in the assessment of conditions associated with increased bone turnover such as Paget disease
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.25 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen (preferred) ​28 days
​Ambient ​7 days
​Refrigerate ​7 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

There is diurnal variation of PINP levels, with the values being higher at night. When serial measurements of PINP are performed, specimens should be collected at the same time of the day.

PINP is metabolized in the liver. In individuals with severe liver disease, clearance from the circulation might be affected resulting in elevated PINP levels.

Some patients who have been exposed to mouse antigens, whether in the environment or as part of treatment or imaging procedures, may have circulating antimouse antibodies. These antibodies may interfere with the assay reagents to produce unreliable PINP assay results.

This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday, Thursday ​1 day ​Procollagen I intact N-terminal (PINP) kit is based on the competitive radioimmunoassay technique.
Reference Lab
Reference Range Information

Reference values have not been established for patients who are <18 years of age.

Adult male: 22-87 mcg/L

Adult female premenopausal: 19-83 mcg/L

Adult female postmenopausal: 16-96 mcg/L

Interpretation
This test should be performed before beginning osteoporosis treatment (ie, prior to the start of therapy) to establish a baseline procollagen I intact N-terminal (PINP) level. Three to 6 months after initiation of therapy, a change of > or =21% (least significant change) from baseline PINP levels indicates an adequate therapeutic response. This assay is specific for the intact trimeric form of PINP.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83519
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.25 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen (preferred) ​28 days
​Ambient ​7 days
​Refrigerate ​7 days
Rejection Criteria
Gross Hemolysis
​Gross Lipemia
​Gross Icterus
Interference

There is diurnal variation of PINP levels, with the values being higher at night. When serial measurements of PINP are performed, specimens should be collected at the same time of the day.

PINP is metabolized in the liver. In individuals with severe liver disease, clearance from the circulation might be affected resulting in elevated PINP levels.

Some patients who have been exposed to mouse antigens, whether in the environment or as part of treatment or imaging procedures, may have circulating antimouse antibodies. These antibodies may interfere with the assay reagents to produce unreliable PINP assay results.

This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
Useful For
​An aid in monitoring antiresorptive and anabolic therapy in patients with osteoporosis
 
An adjunct in the assessment of conditions associated with increased bone turnover such as Paget disease
Reference Range Information

Reference values have not been established for patients who are <18 years of age.

Adult male: 22-87 mcg/L

Adult female premenopausal: 19-83 mcg/L

Adult female postmenopausal: 16-96 mcg/L

Interpretation
This test should be performed before beginning osteoporosis treatment (ie, prior to the start of therapy) to establish a baseline procollagen I intact N-terminal (PINP) level. Three to 6 months after initiation of therapy, a change of > or =21% (least significant change) from baseline PINP levels indicates an adequate therapeutic response. This assay is specific for the intact trimeric form of PINP.
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Tuesday, Thursday ​1 day ​Procollagen I intact N-terminal (PINP) kit is based on the competitive radioimmunoassay technique.
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83519
For most current information refer to the Marshfield Laboratory online reference manual.