Skip Ribbon Commands
Skip to main content
Sign In

25603 Pyruvic Acid, CSF (PYRC)

Pyruvic Acid, CSF (PYRC)
Test Code: PYRCSO
Synonyms/Keywords
ETC, Mitochondrial Electron Transport Chain Defects, Mitochondrial Respiratory Chain Disorders, PC, PDH (Pyruvate Dehydrogenase) Deficiency, PDHC (Pyruvate Dehydrogenase Complex), Pyruvate, Pyruvate Carboxylase Deficiency, Pyruvate Dehydrogenase (PDH) Deficiency, Pyruvate Dehydrogenase Complex (PDHC)
Useful For

This​ test is useful for investigating possible disorders of mitochondrial metabolism, when used in conjunction with CSF lactate, collected at the same time, to determine the lactate-to-pyruvate ratio.

Evaluating patients with neurologic dysfunction and normal blood lactate-to-pyruvate ratios.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Fluid Collection Device ​0.6 mL 0.3 mL
Collection Processing Instructions
Send specimen from vial #2.
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Frozen (preferred) ​7 days
​Ambient 7 days​
​Refrigerate ​7 days
Rejection Criteria
Gross hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories ​Monday, Thursday; Varies ​6 days ​Spectrophotometry (SP)
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories 0.06-0.19 mmol/L
Interpretation
​An elevated lactate-to-pyruvate (L:P) ratio may indicate inherited disorders of the respiratory chain complex, tricarboxylic acid cycle disorders and pyruvate carboxylase deficiency. Respiratory chain defects usually result in L:P ratios above 20.

A low L:P ratio (disproportionately elevated pyruvic acid) may indicate an inherited disorder of pyruvate metabolism. Defects of the pyruvate dehydrogenase complex result in L:P ratios below 10.

The L:P ratio is characteristically normal in other patients. An artifactually high ratio can be found in acutely ill patients.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​84210
Synonyms/Keywords
ETC, Mitochondrial Electron Transport Chain Defects, Mitochondrial Respiratory Chain Disorders, PC, PDH (Pyruvate Dehydrogenase) Deficiency, PDHC (Pyruvate Dehydrogenase Complex), Pyruvate, Pyruvate Carboxylase Deficiency, Pyruvate Dehydrogenase (PDH) Deficiency, Pyruvate Dehydrogenase Complex (PDHC)
Ordering Applications
Ordering Application Description
​Centricity ​Pyruvate-CSF
​Cerner ​Pyruvate-CSF
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​CSF ​Fluid Collection Device ​0.6 mL 0.3 mL
Collection Processing
Send specimen from vial #2.
Specimen Stability Information
Specimen Type Temperature Time
​CSF ​ ​ ​Frozen (preferred) ​7 days
​Ambient 7 days​
​Refrigerate ​7 days
Rejection Criteria
Gross hemolysis
Useful For

This​ test is useful for investigating possible disorders of mitochondrial metabolism, when used in conjunction with CSF lactate, collected at the same time, to determine the lactate-to-pyruvate ratio.

Evaluating patients with neurologic dysfunction and normal blood lactate-to-pyruvate ratios.

Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories 0.06-0.19 mmol/L
Interpretation
​An elevated lactate-to-pyruvate (L:P) ratio may indicate inherited disorders of the respiratory chain complex, tricarboxylic acid cycle disorders and pyruvate carboxylase deficiency. Respiratory chain defects usually result in L:P ratios above 20.

A low L:P ratio (disproportionately elevated pyruvic acid) may indicate an inherited disorder of pyruvate metabolism. Defects of the pyruvate dehydrogenase complex result in L:P ratios below 10.

The L:P ratio is characteristically normal in other patients. An artifactually high ratio can be found in acutely ill patients.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories ​Monday, Thursday; Varies ​6 days ​Spectrophotometry (SP)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​84210
For most current information refer to the Marshfield Laboratory online reference manual.