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25403 ROS1 (6q22) Rearrangement, FISH, Tissue (ROS1F)

ROS1 (6q22) Rearrangement, FISH, Tissue (ROS1F)
Test Code: FROS1SO
Synonyms/Keywords
Lung carcinoma, Non-small cell lung cancer (NSCLC)
Useful For
​Identifying c-ros oncogene 1 (ROS1) gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Tissue
​FFPE
tumor tissue block
​Slides 4 consecutive, unstained, 5 micron thick sections placed on positively charged slides, and 1 H&E slide ​2 consecutive, unstained, 5 micron thick sections placed on positively charged slides, and 1 H&E slide
Collection Processing Instructions

A pathology report is required in order for testing to be performed. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports. Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

For blocks residing at a Non-Clinic location, please complete the Surgical Pathology Specimen Request form found in FORMS PRINTER or located here:

Surgical Pathology Specimen Request

Specimen Stability Information
Specimen Type Temperature
​ Tissue ​Ambient (preferred)
Refrigerated​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories ​Monday through Sunday ​7 days Fluorescence In Situ Hybridization (​FISH)
Reference Lab
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​ ​Interpretive Report
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88291 1 Interpretation and report
​88271​ 2 ​Probe Set, 1ST
​​88271 2 ​Probe, +2 ​as needed
​88271​ ​1 ​Probe, +1 ​as needed
​88271​ ​2 ​Probe, +2 ​as needed
​88271​ ​3 ​Probe, +3 ​as needed
​88274​ ​1 ​Interphases, <25​ ​as needed
​​88274 ​1 ​Interphases, 25-99 ​as needed
​88275​ ​1 ​Interphases, >100 ​as needed
Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
Synonyms/Keywords
Lung carcinoma, Non-small cell lung cancer (NSCLC)
Ordering Applications
Ordering Application Description
COM​​​​ ​ROS1 (6q22) Rearrangement
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Tissue
​FFPE
tumor tissue block
​Slides 4 consecutive, unstained, 5 micron thick sections placed on positively charged slides, and 1 H&E slide ​2 consecutive, unstained, 5 micron thick sections placed on positively charged slides, and 1 H&E slide
Collection Processing

A pathology report is required in order for testing to be performed. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports. Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

For blocks residing at a Non-Clinic location, please complete the Surgical Pathology Specimen Request form found in FORMS PRINTER or located here:

Surgical Pathology Specimen Request

Specimen Stability Information
Specimen Type Temperature
​ Tissue ​Ambient (preferred)
Refrigerated​
Useful For
​Identifying c-ros oncogene 1 (ROS1) gene rearrangements in patients with late-stage, lung adenocarcinomas that are negative for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​ ​Interpretive Report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories ​Monday through Sunday ​7 days Fluorescence In Situ Hybridization (​FISH)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88291 1 Interpretation and report
​88271​ 2 ​Probe Set, 1ST
​​88271 2 ​Probe, +2 ​as needed
​88271​ ​1 ​Probe, +1 ​as needed
​88271​ ​2 ​Probe, +2 ​as needed
​88271​ ​3 ​Probe, +3 ​as needed
​88274​ ​1 ​Interphases, <25​ ​as needed
​​88274 ​1 ​Interphases, 25-99 ​as needed
​88275​ ​1 ​Interphases, >100 ​as needed
Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
For most current information refer to the Marshfield Laboratory online reference manual.