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25381 Spotted Fever IgG, IgM Antibodies (SFGP)

Spotted Fever IgG, IgM Antibodies (SFGP)
Test Code: SFGPSO
Synonyms/Keywords
​Rocky Mountain Spotted Fever
Useful For
​An aid in the diagnosis of spotted fever group rickettsial infections.

Rickettsial infections in the United States are caused by 2 major groups within the genus Rickettsia: spotted fever group and typhus fever group.  The spotted fever group includes Rickettsia rickettsii (Rocky Mountain spotted fever), Rickettsia akari, Rickettsia conorii (Boutonneuse fever), Rickettsia australis (Queensland tick typhus), and Rickettsia typhi (murine typhus; endemic typhus), and Rickettsia prowazekii (epidemic typhus).

Rickettsia rickettsiae is the most common rickettsial species encountered in the United States and is transmitted through a tick vector (Dermacentor species or, less commonly, Rhipicephalus sanguineus).  Following a 2 to 14 day incubation period, patients most commonly present with fever, chills, and myalgia.  A maculopapular rash typically appears 2 to 5 days after fever onset, though approximately 10% of patients will not develop a rash.  Antibodies to the spotted fever group agents are detectable within 7 to 10 days after illness onset.  Demonstration of either 1) seroconversion or 2) a 4-fold change in IgG specific antibody titiers in acute and convalescent serum samples is consistent with acute or ongoing disease. 
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.2 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerate ​14 days
​Frozen ​14 days
Rejection Criteria
Gross hemolysis, Gross lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories who forwards to Beacon Diagnostics Laboratory ​Monday thorugh Friday ​1 day
Test Information
Test Performed By: 
Beacon Diagnostics Laboratory
A Division of Associates of Cape Cod, Inc.
124 Bernard E. Saint Jean Drive
East Falmouth, MA  02536-4445
Reference Range Information
IgG: <1:64
IgM: <1:64
Interpretation
​This test detects reactivity to the group-specific rickettsia.  For example, antibody reactivity to the Rickettsia rickettsii will also react with other organisms within the spotted fever group. 
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86757 ​2 Spotted Fever IgG, IgM​
Synonyms/Keywords
​Rocky Mountain Spotted Fever
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.2 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerate ​14 days
​Frozen ​14 days
Rejection Criteria
Gross hemolysis, Gross lipemia
Useful For
​An aid in the diagnosis of spotted fever group rickettsial infections.

Rickettsial infections in the United States are caused by 2 major groups within the genus Rickettsia: spotted fever group and typhus fever group.  The spotted fever group includes Rickettsia rickettsii (Rocky Mountain spotted fever), Rickettsia akari, Rickettsia conorii (Boutonneuse fever), Rickettsia australis (Queensland tick typhus), and Rickettsia typhi (murine typhus; endemic typhus), and Rickettsia prowazekii (epidemic typhus).

Rickettsia rickettsiae is the most common rickettsial species encountered in the United States and is transmitted through a tick vector (Dermacentor species or, less commonly, Rhipicephalus sanguineus).  Following a 2 to 14 day incubation period, patients most commonly present with fever, chills, and myalgia.  A maculopapular rash typically appears 2 to 5 days after fever onset, though approximately 10% of patients will not develop a rash.  Antibodies to the spotted fever group agents are detectable within 7 to 10 days after illness onset.  Demonstration of either 1) seroconversion or 2) a 4-fold change in IgG specific antibody titiers in acute and convalescent serum samples is consistent with acute or ongoing disease. 
Reference Range Information
IgG: <1:64
IgM: <1:64
Interpretation
​This test detects reactivity to the group-specific rickettsia.  For example, antibody reactivity to the Rickettsia rickettsii will also react with other organisms within the spotted fever group. 
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories who forwards to Beacon Diagnostics Laboratory ​Monday thorugh Friday ​1 day
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86757 ​2 Spotted Fever IgG, IgM​
For most current information refer to the Marshfield Laboratory online reference manual.