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25305 Soluble Liver Antigen Antibodies, IgG

Soluble Liver Antigen Antibodies, IgG
Test Code: SLA
Synonyms/Keywords
SLA, Autoimmune hepatitis, autoimmune liver disease
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH). Soluble liver antigen (SLA) antibodies have been found in patients with type 3 AIH in which the conventional serological markers of AIH (i.e., antinuclear antibody, antismooth muscle antibody, anti-LKM-1 antibody) are absent. SLA testing may aid in establishing a diagnosis of AIH, preventing treatment delay. Definitive diagnosis should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.0 mL ​0.75 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Ambient ​8 hours
​ ​Refrigerate at 2-8 deg Celsius ​2 days
​ ​Freeze at -20 deg Celsius ​> 2 days
Rejection Criteria
Gross Hemolysis, mild OK
​Gross Lipemia, mild OK
​Heat treated samples
​Microbially contaminated samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Tuesday, Thursday ​1 day ​Enzyme Immunoassay (EIA)
Reference Range Information
Performing Location Reference Range
​Marshfield ​<= 20.0 Units Negative
​ ​20.1-24.9 Units Equivocal
​ ​>=25.0 Units Positive
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83516 ​ ​ ​ ​
Synonyms/Keywords
SLA, Autoimmune hepatitis, autoimmune liver disease
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​Serum ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.0 mL ​0.75 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Ambient ​8 hours
​ ​Refrigerate at 2-8 deg Celsius ​2 days
​ ​Freeze at -20 deg Celsius ​> 2 days
Rejection Criteria
Gross Hemolysis, mild OK
​Gross Lipemia, mild OK
​Heat treated samples
​Microbially contaminated samples
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH). Soluble liver antigen (SLA) antibodies have been found in patients with type 3 AIH in which the conventional serological markers of AIH (i.e., antinuclear antibody, antismooth muscle antibody, anti-LKM-1 antibody) are absent. SLA testing may aid in establishing a diagnosis of AIH, preventing treatment delay. Definitive diagnosis should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Reference Range Information
Performing Location Reference Range
​Marshfield ​<= 20.0 Units Negative
​ ​20.1-24.9 Units Equivocal
​ ​>=25.0 Units Positive
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Tuesday, Thursday ​1 day ​Enzyme Immunoassay (EIA)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83516 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.