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25301 Catecholamine/Creatinine Ratio, Urine

Catecholamine/Creatinine Ratio, Urine
Test Code: CAT-RND
Synonyms/Keywords
​Norepinephrine, Epinephrine, Dopamine, Adrenaline
Test Components
​Random Norepinephrine, Epinephrine, Dopamine, Creatinine
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Random Urine ​Sage Cup with 0.1g sulfamic acid 50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5 ​10 mL ​5 mL ​3 mL
Collection Processing Instructions
If random specimens are collected unpreserved, specimen must be hand carried to the lab for immediate addition of 0.1 grams of sulfamic acid. If preferred or acceptable container preservatives are unavailable, the unpreserved sample can be immediately frozen and transported frozen to Marshfield labs.
Specimen Stability Information
Specimen TypeTemperatureTime
Urine​ (preserved) ​Refrigerate​1 week
​Frozen​1 week
​Urine (unpreserved) ​​Refrigerate​48 hours
​Frozen​48 hours
Rejection Criteria
Specimens that are unpreserved and not frozen.
Interference
​Levodopa, Carbidopa, L-Dopa, Aldomet, Methenamine Mandelate
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield

​Monday, Wednesday, Friday

Samples must be in the performing department by 8am on the day of testing for results the same day

​1 day ​UPLC-MS MS (Waters TQ-S system)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Reference Range Information

Norepinephine
<1 year:        0.025-0.310 ug/mg creatinine
1-3 years:     0-025-0.290 ug/mg creatinine
4-9 years:     0.027-0.108 ug/mg creatinine
10-17 years:  0.004-0.105 ug/mg creatinine
>=18 years:   0.009-0.112 ug/mg creatinine

Epinephrine
<1 year:        0.000-0.375 ug/mg creatinine
1-3 years:     0.000-0.082 ug/mg creatinine
4-9 years:     0.005-0.093 ug/mg creatinine
10-17 years:  0.003-0.058 ug/mg creatinine
>=18 years:   0.001-0.044 ug/mg creatinine

Dopamine
<1 year:        0.24-1.29 ug/mg creatinine
1-3 years:     0.08-1.22 ug/mg creatinine
4-9 years:     0.22-0.72 ug/mg creatinine
10-17 years:  0.12-0.45 ug/mg creatinine
>=18 years:   0.03-0.35 ug/mg creatinine

 

Interpretation
​Catecholamines can be excreted into the urine in large amounts in patients with tumors of chromaffin tissue: pheochromocytoma, paraganglioma and neuroblastomas.  Approximately 90% of all pheochromocytomas originate in the adrenal medulla and are characterized by an increased excretion of epinephrine.  Extra adrenal pheochromocytomas (paragangliomas) mainly secrete norepinephrine and can develop anywhere along the course of the sympathetic chain from the neck to the pelvis.  Children are more prone to develop a paraganglioma than are adults.  Elevated catecholamine levels can also be seen with tumors of neural origin: neuroblastomas and gangliomas.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82384
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
​Norepinephrine, Epinephrine, Dopamine, Adrenaline
Test Components
​Random Norepinephrine, Epinephrine, Dopamine, Creatinine
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No ​Random Urine ​Sage Cup with 0.1g sulfamic acid 50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5 ​10 mL ​5 mL ​3 mL
Collection Processing
If random specimens are collected unpreserved, specimen must be hand carried to the lab for immediate addition of 0.1 grams of sulfamic acid. If preferred or acceptable container preservatives are unavailable, the unpreserved sample can be immediately frozen and transported frozen to Marshfield labs.
Specimen Stability Information
Specimen TypeTemperatureTime
Urine​ (preserved) ​Refrigerate​1 week
​Frozen​1 week
​Urine (unpreserved) ​​Refrigerate​48 hours
​Frozen​48 hours
Rejection Criteria
Specimens that are unpreserved and not frozen.
Interference
​Levodopa, Carbidopa, L-Dopa, Aldomet, Methenamine Mandelate
Test Components
​Random Norepinephrine, Epinephrine, Dopamine, Creatinine
Reference Range Information

Norepinephine
<1 year:        0.025-0.310 ug/mg creatinine
1-3 years:     0-025-0.290 ug/mg creatinine
4-9 years:     0.027-0.108 ug/mg creatinine
10-17 years:  0.004-0.105 ug/mg creatinine
>=18 years:   0.009-0.112 ug/mg creatinine

Epinephrine
<1 year:        0.000-0.375 ug/mg creatinine
1-3 years:     0.000-0.082 ug/mg creatinine
4-9 years:     0.005-0.093 ug/mg creatinine
10-17 years:  0.003-0.058 ug/mg creatinine
>=18 years:   0.001-0.044 ug/mg creatinine

Dopamine
<1 year:        0.24-1.29 ug/mg creatinine
1-3 years:     0.08-1.22 ug/mg creatinine
4-9 years:     0.22-0.72 ug/mg creatinine
10-17 years:  0.12-0.45 ug/mg creatinine
>=18 years:   0.03-0.35 ug/mg creatinine

 

Interpretation
​Catecholamines can be excreted into the urine in large amounts in patients with tumors of chromaffin tissue: pheochromocytoma, paraganglioma and neuroblastomas.  Approximately 90% of all pheochromocytomas originate in the adrenal medulla and are characterized by an increased excretion of epinephrine.  Extra adrenal pheochromocytomas (paragangliomas) mainly secrete norepinephrine and can develop anywhere along the course of the sympathetic chain from the neck to the pelvis.  Children are more prone to develop a paraganglioma than are adults.  Elevated catecholamine levels can also be seen with tumors of neural origin: neuroblastomas and gangliomas.
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield

​Monday, Wednesday, Friday

Samples must be in the performing department by 8am on the day of testing for results the same day

​1 day ​UPLC-MS MS (Waters TQ-S system)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82384
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.