This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
6-monoacetylmorphine (6-MAM) is a metabolite of heroin (3,6-diacetylmorphine). When a person uses heroin, the drug is rapidly deacetylated to form 6-MAM. 6-MAM is then deactylated at a slower rate for form morphine. 6-monoacetylmorphine (6-MAM) arises only from metabolism of heroin. It is not found in poppy seeds and is not a metabolic product of morphine, codeine, or any other opiate. Therefore, the presence of 6-MAM in urine is firm evidence of heroin use. Although 6-MAM is present in urine of a majority of heroin users, failure to detect 6-MAM does not rule out heroin, because 6-MAM is only present in low concentrations and for a relatively short time after use of the drug.