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25094 Cocaine Metabolite, Urine, Confirm Only by LCMS

Cocaine Metabolite, Urine, Confirm Only by LCMS
Test Code: CO-COC
Synonyms/Keywords
​Benzoylecgonine
Useful For
​Detecting abuse of cocaine
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation) ​
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 

Cocaine is prepared from the leaves of the tropical bush Erythroxylon coca.  After use (snorting, smoking, or intravenous injection) cocaine is metabolized to benzoylecgonine (BZE) and ecgonine methyl ester (EME).  The BZE metabolite is analyzed since it is the metabolite that is detectable in urine for a longer period of time.

This LC-MS/MS confirmation-only test for BZE is intended for use only in patients where an initial drug screening test has already been performed at the time of specimen collection (i.e. point-of-care drug screening cup, dipstick, etc.). The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LC-MS/MS. If an initial drug screen has not been performed at the specimen collection site, it is more appropriate to order the "Cocaine Metabolite, Urine" (COC) test code which includes an initial screen.

Reference Range Information
Performing Location Reference Range
Marshfield​ ALL:  Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The cocaine metabolite benzoylecgonine can be detected up to 3-5 days after last use.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80353 1​ Cocaine Metabolite Confirm by LC/MS/MS
​G0480 ​1 ​Cocaine Metabolite Confirm by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
​Benzoylecgonine
Ordering Applications
Ordering Application Description
​Centricity ​Cocaine, Urine, Confirm Only by GCMS
​Cerner ​Cocaine, Urine, Confirm Only
​COM ​Cocaine, Urine, Confirm
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Useful For
​Detecting abuse of cocaine
Reference Range Information
Performing Location Reference Range
Marshfield​ ALL:  Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The cocaine metabolite benzoylecgonine can be detected up to 3-5 days after last use.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation) ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80353 1​ Cocaine Metabolite Confirm by LC/MS/MS
​G0480 ​1 ​Cocaine Metabolite Confirm by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.