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25093 Cannabinoids, Urine, Confirm Only by LCMS

Cannabinoids, Urine, Confirm Only by LCMS
Test Code: CO-CAN
Synonyms/Keywords
CBD, Marijuana, THC, Tetrahydrocannabinol​
Useful For
Detecting abuse of marijuana​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 7 mL​ 5 mL​ 3  mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)  
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 

Marijuana is composed of more than sixty C21 compounds found in the leaves and flowering tops of the plant Cannabis sativa L.  These compounds and their metabolites, collectively called cannabinoids, are excreted in the urine of marijuana users.  This test is a confirm-only test for two cannabinoids in urine: 

1.       THCA (or 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid) is the primary metabolite of the psychoactive drug THC found in marijuana and comprises about one third to one half of the cannabinoids found in urine.  

2.       CBD (or cannabidiol) is a cannabinoid also found in marijuana, and has seen a recent surge in over-the-counter supplements that fall into the fringe of legality. Unlike THC, it has no known psychoactive properties.  Currently, the only FDA-approved medical use for CBD is treatment of refractory epilepsy.

This LC-MS/MS confirmation-only test is intended for use only in patients where an initial drug screening test has already been performed at the time of specimen collection (i.e. point-of-care drug screening cup, dipstick, etc.). The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LC-MS/MS. If an initial drug screen has not been performed at the specimen collection site, it is more appropriate to order the "Cannabinoids, Urine" (CAN) test code which includes an initial screen.

Reference Range Information
Performing Location Reference Range
​Marshfield ALL: Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The marijuana metabolite is retained in adipose tissue, and has a widely variable detection time.  In general, single-use can be detected up to 3 days afterward; chronic heavy use can be detected 21-30 days after the last use.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80349 1​ ​Cannabinoids Confirmation by LC/MS/MS
​G0480 ​1 ​Cannabinoids Confirmation by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
CBD, Marijuana, THC, Tetrahydrocannabinol​
Ordering Applications
Ordering Application Description
​Centricity ​Cannabiniods, Urine, Confirm Only by GCMS
​Cerner ​Cannabinoid, Urine, Confirm Only
​COM ​Cannabinoids, Urine, Confirm
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 7 mL​ 5 mL​ 3  mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Useful For
Detecting abuse of marijuana​
Reference Range Information
Performing Location Reference Range
​Marshfield ALL: Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The marijuana metabolite is retained in adipose tissue, and has a widely variable detection time.  In general, single-use can be detected up to 3 days afterward; chronic heavy use can be detected 21-30 days after the last use.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)  
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80349 1​ ​Cannabinoids Confirmation by LC/MS/MS
​G0480 ​1 ​Cannabinoids Confirmation by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.