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25046 Dihydrotestosterone, Serum (DHTS)

Dihydrotestosterone, Serum (DHTS)
Test Code: DIHYDSO
Synonyms/Keywords
5-a-dihydrotestosterone, 5-Alpha-Dihydrotestosterone, Allodihydrotestosterone,
Androstanolone, DHT, Serum Dihydrotestosterone, Stanolone
Useful For
Monitoring patients receiving 5 alpha-reductase inhibitor therapy or chemotherapy
 
Evaluating patients with possible 5 alpha-reductase deficiency
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.6 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerated (preferred) ​7 days
​Frozen ​90 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories Monday, Wednesday, Thursday, Friday ​2 to 8 days
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information

Males

Cord blood: < or =100 pg/mL

< or =6 months: < or =1,200 pg/mL

Tanner Stages 

MeanAgeReference range (pg/mL)
Stage I (>6 months and prepubertal)7.1 years< or =50
Stage II12.1 years< or =200
Stage III13.6 years80-330
Stage IV15.1 years220-520
Stage V18 years240-650

>19 years: 112-955 pg/mL

 

Females

Cord blood: < or =50 pg/mL

< or =6 months: < or =1,200 pg/mL

Tanner Stages 

MeanAgeReference range (pg/mL)
Stage I (>6 months and prepubertal)7.1 years< or =50
Stage II10.5 years< or =300
Stage III11.6 years< or =300
Stage IV12.3 years< or =300
Stage V14.5 years< or =300

20-55 years: < or =300 pg/mL

>55 years: < or =128 pg/mL 

Interpretation
Patients taking 5 alpha-reductase inhibitor have decreased dihydrotestosterone (DHT) serum levels.
 
Patients with genetic 5 alpha-reductase deficiency (a rare disease) also have reduced DHT serum levels.
 
DHT should serve as the primary marker of peripheral androgen production. However, because it is metabolized rapidly and has a very high affinity for sex hormone-binding globulin (SHBG), DHT does not reflect peripheral androgen action. Instead, its distal metabolite, 3 alpha, 17 beta-androstanediol glucuronide, serves as a better marker of peripheral androgen action.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82642 ​ ​1 ​ ​
Synonyms/Keywords
5-a-dihydrotestosterone, 5-Alpha-Dihydrotestosterone, Allodihydrotestosterone,
Androstanolone, DHT, Serum Dihydrotestosterone, Stanolone
Ordering Applications
Ordering Application Description
​Centricity ​Dihydrotestosterone
​Cerner ​Dihydrotestosterone (81479)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.6 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerated (preferred) ​7 days
​Frozen ​90 days
Useful For
Monitoring patients receiving 5 alpha-reductase inhibitor therapy or chemotherapy
 
Evaluating patients with possible 5 alpha-reductase deficiency
Reference Range Information

Males

Cord blood: < or =100 pg/mL

< or =6 months: < or =1,200 pg/mL

Tanner Stages 

MeanAgeReference range (pg/mL)
Stage I (>6 months and prepubertal)7.1 years< or =50
Stage II12.1 years< or =200
Stage III13.6 years80-330
Stage IV15.1 years220-520
Stage V18 years240-650

>19 years: 112-955 pg/mL

 

Females

Cord blood: < or =50 pg/mL

< or =6 months: < or =1,200 pg/mL

Tanner Stages 

MeanAgeReference range (pg/mL)
Stage I (>6 months and prepubertal)7.1 years< or =50
Stage II10.5 years< or =300
Stage III11.6 years< or =300
Stage IV12.3 years< or =300
Stage V14.5 years< or =300

20-55 years: < or =300 pg/mL

>55 years: < or =128 pg/mL 

Interpretation
Patients taking 5 alpha-reductase inhibitor have decreased dihydrotestosterone (DHT) serum levels.
 
Patients with genetic 5 alpha-reductase deficiency (a rare disease) also have reduced DHT serum levels.
 
DHT should serve as the primary marker of peripheral androgen production. However, because it is metabolized rapidly and has a very high affinity for sex hormone-binding globulin (SHBG), DHT does not reflect peripheral androgen action. Instead, its distal metabolite, 3 alpha, 17 beta-androstanediol glucuronide, serves as a better marker of peripheral androgen action.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories Monday, Wednesday, Thursday, Friday ​2 to 8 days
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82642 ​ ​1 ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.