Diagnosis of primary CoQ10 deficiencies in some patients who are not supplemented with CoQ10
Diagnosis of coenzyme Q10 (CoQ10) deficiency in mitochondrial disorders
Monitoring CoQ10 status during treatment of various degenerative conditions including Parkinson and Alzheimer disease
This test is not useful for distinguishing primary CoQ10 deficiencies from acquired CoQ10 deficiencies.
This test is appropriate for the diagnosis of secondary coenzyme Q10 (CoQ10) deficiency, and in some patients with primary CoQ10 deficiency who are not supplemented with CoQ10. It is also used to monitor CoQ10 status in patients with mitochondrial cytopathies, patients receiving statin therapy, or during treatment of various degenerative conditions including Parkinson and Alzheimer diseases.
1. Immediately after collection, place specimen on wet ice. Maintain on wet ice and process within 3 hours of collection.
2. Centrifuge, separate plasma from cells, and immediately freeze specimen.
If possible, do not send other tests ordered on same vial of plasma. In doing so, the other tests may have increased turnaround time due to the strict frozen criteria of this assay.
Coenzyme Q10 (CoQ10) is sensitive to specimen handling and transport temperature. Failure to follow the specimen handling and transportation recommendations may lead to false-positive results.
Abnormal results are reported with a detailed interpretation including an overview of the results and their significance, a correlation to available clinical information provided with the specimen, differential diagnosis, and recommendations for additional testing when indicated and available.