Skip Ribbon Commands
Skip to main content
Sign In

24970 Beta-Crosslaps (Beta-CTx), Serum (CTX)

Beta-Crosslaps (Beta-CTx), Serum (CTX)
Test Code: BCTXSO
Synonyms/Keywords
B-CTx, Beta CrossLaps, Beta-CTx, C-Telopeptide, C-terminal collagen crosslinks, Carboxy terminal collagen crosslinks, CTx
Useful For
Monitoring antiresorptive therapies (eg, bisphosphonates and hormone replacement therapy) in postmenopausal women treated for osteoporosis and individuals diagnosed with osteopenia
 
An adjunct in the diagnosis of medical conditions associated with increased bone turnover
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Fasting. Draw specimen prior to 10 a.m.​ Serum​ ​Red Top tube (RTT) ​Serum Separator Tube (SST) 1 mL​ ​0.75 mL
Collection Processing Instructions

For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Frozen (preferred) ​90 days
Refrigerated ​ ​72 hours
Rejection Criteria
Hemolysis
Gross reject
Interference

Reduced renal function may lead to reduced urinary excretion of beta-C-terminal telopeptide (CTx) and a consequent increase in the apparent serum beta-CTx concentration.

As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from specimens taken from patients who have been treated with monoclonal mouse antibodies or have received them for diagnostic purposes.

In rare cases, interference due to extremely high titers of antibodies to ruthenium or streptavidin can occur.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Saturday
1 to 3 days
Electrochemiluminescence Immunoassay (ECLIA)
Reference Lab
Reference Range Information

Reference Range

Males

<5 years: 242-1292 pg/mL

5-9 years: 351-1532 pg/mL

10-15 years: 447-2457 pg/mL

16-17 years: 478-1666 pg/mL

18-30 years: 120-946 pg/mL

31-50 years: 93-630 pg/mL

51-70 years: 35-836 pg/mL

>70 years: not established

 

Females

<5 years: 347-1508 pg/mL

5-9 years: 383-1556 pg/mL

10-15 years: 311-1776 pg/mL

16-17 years: 146-1266 pg/mL

Premenopausal: 25-573 pg/mL

Postmenopausal: 104-1008 pg/mL

 

Interpretation
Elevated levels of beta-CTx indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget's disease, hyperthyroidism, and hyperparathyroidism.
 
In patients taking antiresorptive agents (bisphosphonates or hormone replacement therapy), a decrease of 25% or more from baseline beta-CTx levels (ie, prior to the start of therapy) 3 to 6 months after initiation of therapy indicates an adequate therapeutic response.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82523
Synonyms/Keywords
B-CTx, Beta CrossLaps, Beta-CTx, C-Telopeptide, C-terminal collagen crosslinks, Carboxy terminal collagen crosslinks, CTx
Ordering Applications
Ordering Application Description
​Centricity ​Beta-CrossLaps (B-Ctx), Serum (83175)
​Cerner ​None
​COM ​Beta-CrossLaps (B-CTx), Serum
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Fasting. Draw specimen prior to 10 a.m.​ Serum​ ​Red Top tube (RTT) ​Serum Separator Tube (SST) 1 mL​ ​0.75 mL
Collection Processing

For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Frozen (preferred) ​90 days
Refrigerated ​ ​72 hours
Rejection Criteria
Hemolysis
Gross reject
Interference

Reduced renal function may lead to reduced urinary excretion of beta-C-terminal telopeptide (CTx) and a consequent increase in the apparent serum beta-CTx concentration.

As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from specimens taken from patients who have been treated with monoclonal mouse antibodies or have received them for diagnostic purposes.

In rare cases, interference due to extremely high titers of antibodies to ruthenium or streptavidin can occur.

Useful For
Monitoring antiresorptive therapies (eg, bisphosphonates and hormone replacement therapy) in postmenopausal women treated for osteoporosis and individuals diagnosed with osteopenia
 
An adjunct in the diagnosis of medical conditions associated with increased bone turnover
Reference Range Information

Reference Range

Males

<5 years: 242-1292 pg/mL

5-9 years: 351-1532 pg/mL

10-15 years: 447-2457 pg/mL

16-17 years: 478-1666 pg/mL

18-30 years: 120-946 pg/mL

31-50 years: 93-630 pg/mL

51-70 years: 35-836 pg/mL

>70 years: not established

 

Females

<5 years: 347-1508 pg/mL

5-9 years: 383-1556 pg/mL

10-15 years: 311-1776 pg/mL

16-17 years: 146-1266 pg/mL

Premenopausal: 25-573 pg/mL

Postmenopausal: 104-1008 pg/mL

 

Interpretation
Elevated levels of beta-CTx indicate increased bone resorption. Increased levels are associated with osteoporosis, osteopenia, Paget's disease, hyperthyroidism, and hyperparathyroidism.
 
In patients taking antiresorptive agents (bisphosphonates or hormone replacement therapy), a decrease of 25% or more from baseline beta-CTx levels (ie, prior to the start of therapy) 3 to 6 months after initiation of therapy indicates an adequate therapeutic response.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Saturday
1 to 3 days
Electrochemiluminescence Immunoassay (ECLIA)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82523
For most current information refer to the Marshfield Laboratory online reference manual.