Skip Ribbon Commands
Skip to main content
Sign In

24902 Total Light Chains, Urine (TLCU)

Total Light Chains, Urine (TLCU)
Test Code: TLCUSO
Synonyms/Keywords
Immunoglobulin Light Chains, Kappa Light Chains, Lambda Light Chains, Light Chains, Kappa and Lambda, Urine Light Chains
Useful For
Monitoring patients whose urines demonstrate large M-spikes
 
Confirming the quantitation of specimens that show M-spikes by electrophoresis
 
Detecting urine monoclonal proteins and identification of specimens that need urine protein electrophoresis​
Specimen Requirements

Specimen Type

Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​ ​ ​ Submit only 1 of the following specimens​: ​ ​
Urine(24 hours)​ ​Plastic, 10-mL urine tube ​1.0 mL 0.5 mL​
Urine (random)​ Plastic, 10-mL urine tube​ ​1.0 mL ​0.5 mL
Collection Processing Instructions
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerated (preferred) ​7 days
​Frozen ​20 days
​Ambient ​72 hours
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Saturday​ ​Same day/1 day
Nephelometry​
Reference Lab
Test Information
If serum is being submitted on the same patient for FLCP/84190 Immunoglobulin Free Light Chains, Serum; order that test under a different order.
Reference Range Information
Kappa Total Light Chain: <0.9 mg/dL
Lambda Total Light Chain: <0.7 mg/dL
Kappa / Lambda Ratio: 0.7-6.2
Interpretation
A kappa/lambda (K/L) ratio >6.2 suggests the presence of monoclonal kappa light chains.
 
A K/L ratio <0.7 suggests the presence of monoclonal lambda light chains.
 
In 24-hour specimens, a >90% increase in concentration suggests progression or relapse; a >90% decrease suggests treatment response.
 
Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83883 ​2
Synonyms/Keywords
Immunoglobulin Light Chains, Kappa Light Chains, Lambda Light Chains, Light Chains, Kappa and Lambda, Urine Light Chains
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements

Specimen Type

Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​ ​ ​ Submit only 1 of the following specimens​: ​ ​
Urine(24 hours)​ ​Plastic, 10-mL urine tube ​1.0 mL 0.5 mL​
Urine (random)​ Plastic, 10-mL urine tube​ ​1.0 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerated (preferred) ​7 days
​Frozen ​20 days
​Ambient ​72 hours
Useful For
Monitoring patients whose urines demonstrate large M-spikes
 
Confirming the quantitation of specimens that show M-spikes by electrophoresis
 
Detecting urine monoclonal proteins and identification of specimens that need urine protein electrophoresis​
Reference Range Information
Kappa Total Light Chain: <0.9 mg/dL
Lambda Total Light Chain: <0.7 mg/dL
Kappa / Lambda Ratio: 0.7-6.2
Interpretation
A kappa/lambda (K/L) ratio >6.2 suggests the presence of monoclonal kappa light chains.
 
A K/L ratio <0.7 suggests the presence of monoclonal lambda light chains.
 
In 24-hour specimens, a >90% increase in concentration suggests progression or relapse; a >90% decrease suggests treatment response.
 
Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Saturday​ ​Same day/1 day
Nephelometry​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83883 ​2
For most current information refer to the Marshfield Laboratory online reference manual.