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24902 Total Light Chains, Urine (TLCU)

Total Light Chains, Urine (TLCU)
Test Code: TLCUSO
Synonyms/Keywords

Immunoglobulin Light Chains, Kappa Light Chains, Lambda Light Chains, Light Chains, Kappa and Lambda, Urine Light Chains,

Immunoglobulin Total Light Chains, Urine

U TLCUSO

Useful For
Monitoring patients whose urine demonstrates large M-spikes
 
Confirming the quantitation of specimens that show M-spikes by electrophoresis
 
Detecting urine monoclonal proteins and identification of specimens that need urine protein electrophoresis​
Specimen Requirements

Specimen Type

Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​ ​ ​ Submit only 1 of the following specimens​: ​ ​
Urine(24 hours)​ ​Plastic, 10-mL urine tube ​1.0 mL 0.5 mL​
Urine (random)​ Plastic, 10-mL urine tube​ ​1.0 mL ​0.5 mL
Collection Processing Instructions
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerated (preferred) ​7 days
​Frozen ​20 days
​Ambient ​72 hours
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​ ​1 day
KTLCU, LTLCU: Nephelometry​
Reference Lab
Test Information
If serum is being submitted on the same patient for FLCP/ Immunoglobulin Free Light Chains, Serum; order that test under a different order.
Reference Range Information
Kappa Total Light Chain: <0.9 mg/dL
Lambda Total Light Chain: <0.7 mg/dL
Kappa / Lambda Ratio: 0.7-6.2
Interpretation
A kappa/lambda (K/L) ratio >6.2 suggests the presence of monoclonal kappa light chains.
 
A K/L ratio <0.7 suggests the presence of monoclonal lambda light chains.
 
In 24-hour specimens, a >90% increase in concentration suggests progression or relapse; a >90% decrease suggests treatment response.
 
Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83883 ​2
Synonyms/Keywords

Immunoglobulin Light Chains, Kappa Light Chains, Lambda Light Chains, Light Chains, Kappa and Lambda, Urine Light Chains,

Immunoglobulin Total Light Chains, Urine

U TLCUSO

Ordering Applications
Ordering Application Description
​COM​Total Light Chains, U (TLCU)
​Cerner​Total Light Chains, Urine (TLCU)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements

Specimen Type

Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​ ​ ​ ​ ​ Submit only 1 of the following specimens​: ​ ​
Urine(24 hours)​ ​Plastic, 10-mL urine tube ​1.0 mL 0.5 mL​
Urine (random)​ Plastic, 10-mL urine tube​ ​1.0 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerated (preferred) ​7 days
​Frozen ​20 days
​Ambient ​72 hours
Useful For
Monitoring patients whose urine demonstrates large M-spikes
 
Confirming the quantitation of specimens that show M-spikes by electrophoresis
 
Detecting urine monoclonal proteins and identification of specimens that need urine protein electrophoresis​
Reference Range Information
Kappa Total Light Chain: <0.9 mg/dL
Lambda Total Light Chain: <0.7 mg/dL
Kappa / Lambda Ratio: 0.7-6.2
Interpretation
A kappa/lambda (K/L) ratio >6.2 suggests the presence of monoclonal kappa light chains.
 
A K/L ratio <0.7 suggests the presence of monoclonal lambda light chains.
 
In 24-hour specimens, a >90% increase in concentration suggests progression or relapse; a >90% decrease suggests treatment response.
 
Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Friday​ ​1 day
KTLCU, LTLCU: Nephelometry​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83883 ​2
For most current information refer to the Marshfield Laboratory online reference manual.