Levetiracetam, Serum

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Test Code: LEVE

Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding

Synonyms/Keywords

Keppra, Leviteracetam

Useful For

This test is useful for monitoring leviteracetam (anticonvulsant) levels. Leviteracetam is approved for adjunctive therapy in the treatment of partial onset seizures in adults and children, 4 years or older, with epilepsy

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Red Top Tube (RTT)		0.5 mL	0.5 mL	0.3 mL

Collection Processing Instructions

Separate serum/plasma from cells within 2 hours of collection.

Specimens collected in serum separator tube (SST) will be rejected.

Heparinized or ETDA plasma collected in a green top or lavender top tube will be rejected

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Ambient	48 hours
	Refrigerate	2 weeks
	Frozen	3 months

Rejection Criteria

Specimens collected in a serum or plasma separator tube

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Marshfield	Monday, Wednesday, Friday	6-8 hours	UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System
Samples must be in performing department by 8am on day of testing for results the same day. Testing may be batched and set up on alternative days of the week as needed.

Test Information

This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.

Reference Range Information

Performing Location	Reference Range
Marshfield	Peak concentration: 10-63 ug/mL Trough concentration: 3-34 ug/mL

Performing Location

Reference Range

Marshfield

Peak concentration: 10-63 ug/mL

Trough concentration: 3-34 ug/mL

Interpretation

Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
80177

Synonyms/Keywords

Keppra, Leviteracetam

Ordering Applications

Ordering Application	Description
COM	Levetiracetam
Cerner	Levetiracetam Level

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Red Top Tube (RTT)		0.5 mL	0.5 mL	0.3 mL

Collection Processing