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24812 Allergen, Weed Panel #1 (WEED1)

Allergen, Weed Panel #1 (WEED1)
Test Code: ALWD1SO
Synonyms/Keywords
IgE Antibodies, Multi-Allergen
Includes: English Plantain, Lamb's Quarters, Mugwort, Short Ragweed, Russian Thistle
Test Components
​Includes: English Plantain, Lamb's Quarters, Mugwort, Short Ragweed, Russian Thistle
Useful For

Establishing a diagnosis of an allergy to English plantain, lamb's quarters, mugwort, Russian thistle, and short ragweed allergen

Defining the allergen responsible for eliciting signs and symptoms

Identifying allergens:

-Responsible for allergic disease and/or anaphylactic episode

-To confirm sensitization prior to beginning immunotherapy

Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

Highlights:

This multi-allergen IgE antibody panel, combined with measurement of IgE in serum, is an appropriate first-order test for allergic disease.

It requires less specimen volume and less cost for ruling out allergic response; however, individual (single) allergen responses cannot be identified. In cases of a positive test, follow-up testing must be performed to differentiate between individual allergens in the panel.

Note: Only one result is generated for each panel. 

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL
0.3 mL
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerated (preferred)​ ​14 days
​Frozen​90 days
Interference

Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.

Since only one result is generated for this panel, individual (single) allergen responses cannot be identified. When this panel is positive, follow-up testing is required to differentiate between individual allergens in the panel.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​ Monday through Friday​
1 to 3 days
Fluorescence Enzyme Immunoassay (FEIA)
Reference Lab
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​
ClassIgE kU/LInterpretation
0<0.35Negative
10.35-0.69Equivocal
20.70-3.49Positive
33.50-17.4Positive
417.5-49.9Strongly positive
550.0-99.9Strongly positive
6> or =100Strongly positive

Reference values apply to all ages.

Interpretation

Positive results indicate the possibility of allergic disease induced by one or more allergens present in the multi-allergen cap.

Negative results may rule out allergy, except in rare cases of allergic disease induced by exposure to a single allergen.

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86003​
Synonyms/Keywords
IgE Antibodies, Multi-Allergen
Includes: English Plantain, Lamb's Quarters, Mugwort, Short Ragweed, Russian Thistle
Test Components
​Includes: English Plantain, Lamb's Quarters, Mugwort, Short Ragweed, Russian Thistle
Ordering Applications
Ordering Application Description
​Centricity ​Allergen Panel, Weed #1
​Cerner ​None
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL
0.3 mL
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerated (preferred)​ ​14 days
​Frozen​90 days
Interference

Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive results for IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.

Since only one result is generated for this panel, individual (single) allergen responses cannot be identified. When this panel is positive, follow-up testing is required to differentiate between individual allergens in the panel.

Useful For

Establishing a diagnosis of an allergy to English plantain, lamb's quarters, mugwort, Russian thistle, and short ragweed allergen

Defining the allergen responsible for eliciting signs and symptoms

Identifying allergens:

-Responsible for allergic disease and/or anaphylactic episode

-To confirm sensitization prior to beginning immunotherapy

Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

Highlights:

This multi-allergen IgE antibody panel, combined with measurement of IgE in serum, is an appropriate first-order test for allergic disease.

It requires less specimen volume and less cost for ruling out allergic response; however, individual (single) allergen responses cannot be identified. In cases of a positive test, follow-up testing must be performed to differentiate between individual allergens in the panel.

Note: Only one result is generated for each panel. 

Test Components
​Includes: English Plantain, Lamb's Quarters, Mugwort, Short Ragweed, Russian Thistle
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​
ClassIgE kU/LInterpretation
0<0.35Negative
10.35-0.69Equivocal
20.70-3.49Positive
33.50-17.4Positive
417.5-49.9Strongly positive
550.0-99.9Strongly positive
6> or =100Strongly positive

Reference values apply to all ages.

Interpretation

Positive results indicate the possibility of allergic disease induced by one or more allergens present in the multi-allergen cap.

Negative results may rule out allergy, except in rare cases of allergic disease induced by exposure to a single allergen.

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​ Monday through Friday​
1 to 3 days
Fluorescence Enzyme Immunoassay (FEIA)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86003​
For most current information refer to the Marshfield Laboratory online reference manual.