Skip Ribbon Commands
Skip to main content
Navigate Up
Search
Test Code
Search
Laboratory Section
Test Category
Browse By Test Name
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Comprehensive Antiphospholipid Syndrome
Test Code: CAPS
Synonyms/Keywords
​DRVVT, PTTLA, ACLSCN, B2GSCRN
Test Components
​Prothrombin Time, Activated Partial Thromboplastin Time, Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA), Beta 2 Glycoprotein Screen (B2GSCRN), Cardiolipin Ab Screen (ACLSCN)
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum
and *Platelet Poor Plasma
Red Top Tube (RTT) and 3.2% Citrated Blue Top Tube (BTT)​ Serum Separator Tube (SST)​ 1.0 mL serum and 6.75 mL citrated plasma divided into two 1.5 mL aliquots and five 0.75 mL aliquots​ 1.0 mL serum and  4.5 mL citrated plasma divided into two 1.5 mL aliquots and two 0.75 mL aliquots​ 1.0 mL serum and 3.0 mL citrated plasma divided into one 1.5 mL aliquot and two 0.75 mL aliquots​
Collection Processing Instructions
Serum (RTT or SST):  Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in a SST must be processed and serum removed from the primary tube within 4 hours for storage or transport.
 
Citrated Plasma (BBT):  Collect in approximately 4-5 Citrated Blue Top Tubes (BTT).  The minimum 3.0 mL citrated platelet poor plasma volume can usually be obtained by drawing two 4.5 mL OR three 2.7 mL blue top tubes. 
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated ​2 days
​Frozen ​6 months
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluid
​Specimens that thaw during storage or transport
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ PT, APTT: Monday - Friday​ Less than 2 hours​ PT, APTT/Siemens BCSXP​
PT substitution: Monday - Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
APTT substitution: Monday - Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
DRVVT: Monday, Wednesday, Friday Less than 2 hours​ Optical clot detection/Siemens BCSXP​
PTTLA: Monday, Wednesday, Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
ACLSCN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2GSCRN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
Factor Assays: Monday - Friday​ Less than 2 hours​ Modified PT/APTT substitution/Siemens BCSXP  ​
ACLA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
ACLG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
ACLM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
Test Information
​Prothrombin Time, Activated Partial Thromboplastin Time, Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTTLA), Beta 2 Glycoprotein Screen (B2GSCRN), and Cardiolipin Ab Screen (ACLSCN) will be performed. If the PT and/or APTT are prolonged mixing studies will be performed.  Reflex testing for factor assays will be performed based on the results of PT (INR) and/or APTT mixing studies and the basic coagulation scheme.  If the ACLSCN is positive an Anticardiolipin IgA (ACLA), Anticardiolipin IgG (ACLG) and an Anticardiolipin IgM (ACLM) will be performed.  If the B2GSCRN is positive a Beta-2-Glycoprotein I IgA (B2IGA), Beta-2-Glycoprotein I IgG (B2IGG) and a Beta-2-Glycoprotein I IgM (B2IGM) will be performed.
 
Requested panel includes Lupus anticoagulant testing (DRVVT and PTT-LA), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, edoxaban, or warfarin.  For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
85610​ Protime ​
85730​ APTT​
85613​ DRVVT​
85732​ PTTLA​
86147​ ACL Screen​
86146​ Beta 2 Glycoprotein Screen​
86146​ 3​ Beta 2 Glycoprotein IgA, IgG, IgM​ If needed
86147​ 3​ ACL IgA, IgG, IgM ​ If needed
85611​ PT substitution ​ If needed
85732​ 3​ APTT substitution ​ If needed
Varies​ Factor assays vary with follow-up​
Synonyms/Keywords
​DRVVT, PTTLA, ACLSCN, B2GSCRN
Test Components
​Prothrombin Time, Activated Partial Thromboplastin Time, Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA), Beta 2 Glycoprotein Screen (B2GSCRN), Cardiolipin Ab Screen (ACLSCN)
Ordering Applications
Ordering Application Description
​Centricity ​Comprehensive Antiphospholipid
​Cerner ​Comprehensive Antiphospholipid
​COM ​Comprehensive Antiphospholipid
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum
and *Platelet Poor Plasma
Red Top Tube (RTT) and 3.2% Citrated Blue Top Tube (BTT)​ Serum Separator Tube (SST)​ 1.0 mL serum and 6.75 mL citrated plasma divided into two 1.5 mL aliquots and five 0.75 mL aliquots​ 1.0 mL serum and  4.5 mL citrated plasma divided into two 1.5 mL aliquots and two 0.75 mL aliquots​ 1.0 mL serum and 3.0 mL citrated plasma divided into one 1.5 mL aliquot and two 0.75 mL aliquots​
Collection Processing Instructions
Serum (RTT or SST):  Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in a SST must be processed and serum removed from the primary tube within 4 hours for storage or transport.
 
Citrated Plasma (BBT):  Collect in approximately 4-5 Citrated Blue Top Tubes (BTT).  The minimum 3.0 mL citrated platelet poor plasma volume can usually be obtained by drawing two 4.5 mL OR three 2.7 mL blue top tubes. 
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated ​2 days
​Frozen ​6 months
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluid
​Specimens that thaw during storage or transport
Test Information
​Prothrombin Time, Activated Partial Thromboplastin Time, Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTTLA), Beta 2 Glycoprotein Screen (B2GSCRN), and Cardiolipin Ab Screen (ACLSCN) will be performed. If the PT and/or APTT are prolonged mixing studies will be performed.  Reflex testing for factor assays will be performed based on the results of PT (INR) and/or APTT mixing studies and the basic coagulation scheme.  If the ACLSCN is positive an Anticardiolipin IgA (ACLA), Anticardiolipin IgG (ACLG) and an Anticardiolipin IgM (ACLM) will be performed.  If the B2GSCRN is positive a Beta-2-Glycoprotein I IgA (B2IGA), Beta-2-Glycoprotein I IgG (B2IGG) and a Beta-2-Glycoprotein I IgM (B2IGM) will be performed.
 
Requested panel includes Lupus anticoagulant testing (DRVVT and PTT-LA), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, edoxaban, or warfarin.  For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ PT, APTT: Monday - Friday​ Less than 2 hours​ PT, APTT/Siemens BCSXP​
PT substitution: Monday - Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
APTT substitution: Monday - Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
DRVVT: Monday, Wednesday, Friday Less than 2 hours​ Optical clot detection/Siemens BCSXP​
PTTLA: Monday, Wednesday, Friday​ Less than 2 hours​ Optical clot detection/Siemens BCSXP​
ACLSCN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2GSCRN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
Factor Assays: Monday - Friday​ Less than 2 hours​ Modified PT/APTT substitution/Siemens BCSXP  ​
ACLA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
ACLG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
ACLM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
B2IGM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
85610​ Protime ​
85730​ APTT​
85613​ DRVVT​
85732​ PTTLA​
86147​ ACL Screen​
86146​ Beta 2 Glycoprotein Screen​
86146​ 3​ Beta 2 Glycoprotein IgA, IgG, IgM​ If needed
86147​ 3​ ACL IgA, IgG, IgM ​ If needed
85611​ PT substitution ​ If needed
85732​ 3​ APTT substitution ​ If needed
Varies​ Factor assays vary with follow-up​
For most current information refer to the Marshfield Laboratory online reference manual.