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23174 FibroSpect HCV, Prometheus (4000)

FibroSpect HCV, Prometheus (4000)
Test Code: FIBROSO
Synonyms/Keywords
​Prometheus Fibrospect II
Test Components

Alpha-2 macroglobulin
Hyaluronic Acid
Tissue Inhibitor Metaloproteinase Type 1
FIBROSpect HCV Index

Useful For
The PROMETHEUS® FIBROSpect® HCV test helps detect, stage, and monitor liver fibrosis in hepatitis C (HCV) patients. The test is a non-invasive, serum diagnostic that provides a quantitative fibrosis score to help physicians risk stratify and monitor patients based on 3 clinically relevant biomarkers.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST) ​Red Top Tube (RTT) ​2 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Ambient ​7 days
​Refrigerated ​30 days
Rejection Criteria
​Gross Hemolysis, Gross Lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Prometheus Therapeutic & Diagnostics Laboratory​ ​Monday through Friday ​7 days AMG: Nephelometry
TIMP-1: Chemiluninescent
Reference Lab
Prometheus Biosciences
Reference Range Information
Performing Location Index Reference Range
​Prometheus Labs

​0-41 Consistent with fibrosis score F0-F1

42-100 Consistent with fibrosis score F2-F4

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83520​ ​ ​1 ​​Hyaluronic Acid ​
​83883 ​ ​1 ​a2-macroglobulin (AMG) by Nephlometry ​
​82397 ​ ​1 ​TIMP-1 ​
Synonyms/Keywords
​Prometheus Fibrospect II
Test Components

Alpha-2 macroglobulin
Hyaluronic Acid
Tissue Inhibitor Metaloproteinase Type 1
FIBROSpect HCV Index

Ordering Applications
Ordering Application Description
​Centricity ​Fibrospect II (#4000)
​Cerner ​Fibrospect II, Prometheus (4000)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST) ​Red Top Tube (RTT) ​2 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Ambient ​7 days
​Refrigerated ​30 days
Rejection Criteria
​Gross Hemolysis, Gross Lipemia
Useful For
The PROMETHEUS® FIBROSpect® HCV test helps detect, stage, and monitor liver fibrosis in hepatitis C (HCV) patients. The test is a non-invasive, serum diagnostic that provides a quantitative fibrosis score to help physicians risk stratify and monitor patients based on 3 clinically relevant biomarkers.
Test Components

Alpha-2 macroglobulin
Hyaluronic Acid
Tissue Inhibitor Metaloproteinase Type 1
FIBROSpect HCV Index

Reference Range Information
Performing Location Index Reference Range
​Prometheus Labs

​0-41 Consistent with fibrosis score F0-F1

42-100 Consistent with fibrosis score F2-F4

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Prometheus Therapeutic & Diagnostics Laboratory​ ​Monday through Friday ​7 days AMG: Nephelometry
TIMP-1: Chemiluninescent
Reference Lab
Prometheus Biosciences
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83520​ ​ ​1 ​​Hyaluronic Acid ​
​83883 ​ ​1 ​a2-macroglobulin (AMG) by Nephlometry ​
​82397 ​ ​1 ​TIMP-1 ​
For most current information refer to the Marshfield Laboratory online reference manual.