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Lab Test Reference Manual
Human Reference Manual
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23163
Lab Test Reference Manual
Human Reference Manual
Currently selected
23163
Free Light Chains, Serum
Marshfield Lab Public WebSite
Marshfield Clinic Public WebSite
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Site Contents
Free Light Chains, Serum
Test Code: FLC-S
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
Kappa and Lambda, Kappa/Lambda ratio, K/L ratio
Test Components
Test Components
Serum Free Kappa Light Chains and Serum Free Lambda Light Chains
Useful For
Useful For
Quantitation of serum free light chain (FLC) levels is important for diagnosis and monitoring of monoclonal gammopathies, including Light Chain Diseases. High serum concentrations are associated with primary amyloidosis, autoimmune disease, monoclonal gammopathies, or malignant plasma cell proliferation.
Specimen Requirements
Specimen Requirements
Fasting Required
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
1.0 mL
0.5 mL
0.5 mL
Collection Processing Instructions
Collection Processing
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Refrigerate
3 weeks
Frozen
1 year
Rejection Criteria
Rejection Criteria
Plasma samples
Gross hemolysis
Gross lipemia
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Marshfield
Monday through Friday
6-8 hours
Turbidimetric method/The Binding Site Optilite analyzer
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Marshfield
Kappa Free Light Chain: 0.33-1.94 mg/dL
Lambda Free Light Chain: 0.57-2.63 mg/dL
Kappa/Lambda ratio: 0.26-1.65
Interpretation
Interpretations
Diagnosis cannot be made and treatment must not be given on the basis of free light chain measurements alone. Clinical history and other laboratory findings must be taken into account. Elevation of both kappa and lambda free light chains with a normal K/L ratio may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
83521
2
Kappa Serum Free Light Chain, Lambda Serum Free Light Chain
Synonyms/Keywords
Synonyms, Keywords
Kappa and Lambda, Kappa/Lambda ratio, K/L ratio
Test Components
Test Components
Serum Free Kappa Light Chains and Serum Free Lambda Light Chains
Ordering Applications
Ordering Applications
Ordering Application
Description
Cerner
Free Light Chains, Serum
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Fasting Required
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
1.0 mL
0.5 mL
0.5 mL
Collection Processing
Collection Processing
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Refrigerate
3 weeks
Frozen
1 year
Rejection Criteria
Rejection Criteria
Plasma samples
Gross hemolysis
Gross lipemia
Useful For
Useful For
Quantitation of serum free light chain (FLC) levels is important for diagnosis and monitoring of monoclonal gammopathies, including Light Chain Diseases. High serum concentrations are associated with primary amyloidosis, autoimmune disease, monoclonal gammopathies, or malignant plasma cell proliferation.
Test Components
Test Components
Serum Free Kappa Light Chains and Serum Free Lambda Light Chains
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Marshfield
Kappa Free Light Chain: 0.33-1.94 mg/dL
Lambda Free Light Chain: 0.57-2.63 mg/dL
Kappa/Lambda ratio: 0.26-1.65
Interpretation
Interpretations
Diagnosis cannot be made and treatment must not be given on the basis of free light chain measurements alone. Clinical history and other laboratory findings must be taken into account. Elevation of both kappa and lambda free light chains with a normal K/L ratio may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Marshfield
Monday through Friday
6-8 hours
Turbidimetric method/The Binding Site Optilite analyzer
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
83521
2
Kappa Serum Free Light Chain, Lambda Serum Free Light Chain
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For most current information refer to the Marshfield Laboratory online reference manual.