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23145 NMR Lipoprotein Quant 123638

NMR Lipoprotein Quant 123638
Test Code: NMRLISO
Synonyms/Keywords
​NMR, Small dense LDL, HDL-C
Test Components
Historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides).
Useful For
NMR LDL-P is a management tool used in appropriate high-risk patients (type 2 diabetes mellitus, metabolic syndrome, CVD risk equivalent, statin-treated patients) to adjudicate response to treatment and guide adjustment in therapy. It is used in conjunction with other lipid measurements and clinical evaluation to aid in the management of lipoprotein disorders associated with cardiovascular disease
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Overnight fasting preferred ​ ​Serum ​Red Top Tube (RTT) 2 mL ​1 mL
​Plasma ​EDTA Lavendar Top Tube (LTT) 2 mL ​1 mL
Collection Processing Instructions

​Patient should be fasting for 12 to 14 hours.

Collect specimen in NMR LipoTube (black-and-yellow-top tube), which is the preferred container. Plain red-top, green-top (heparin-no gel), or lavender-top (EDTA-no gel) tubes are also acceptable. Serum or plasma drawn in gel-barrier collection tubes other than the NMR LipoTube should not be used. The LipoTube is the only acceptable gel-barrier tube. Gently invert tube 8 to 10 times to mix contents and allow specimen to clot for 30 minutes upright at room temperature prior to centrifugation (Plasma tubes should not clot). Centrifuge specimen within two hours of collection at 1800xg for 10 to 15 minutes to separate serum/plasma from the red cells and to avoid red cell contamination during shipment. If the sample cannot be centrifuged immediately, the sample should be refrigerated (at 2ºC to 8ºC) and centrifuged within 24 hours of collection. Note: Centrifuging the specimen while still cold may negatively affect the migration of the gel to the serum/red cell interface and may increase the likelihood of specimens being contaminated with red cells during shipment. All specimens should be centrifuged by the client, prior to shipment to LabCorp, to ensure sample integrity. Do not open NMR LipoTube (black-and-yellow-top). Immediately after centrifugation, pipette separated red-top serum or green-top/lavender-top plasma into a transport tube and label accordingly (serum, heparin plasma, EDTA plasma). Keep samples refrigerated until shipment to the laboratory and ship with frozen cool packs.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​Refrigerate (preferred) ​6 days
Samples drawn at regional centers or outreach facilities should not be drawn on Friday.​ ​ ​
Rejection Criteria
Unspun Samples
​Plasma/Serum contaminated with red cells
​Citrated Plasma (Light Blue Top Tube)

​Gross Hemolysis

​Stored ambient for more than 24 hours
Sample more than 6 days old
Interference

​Refrigerate all acceptable tube types as soon as possible after centrifugation and within 24 hours of collection. Keep refrigerated prior to shipment, and ship on frozen cool packs. Do not store at room temperature. Do not freeze the sample. Sample is stable refrigerated for six days.

If triglyceride level is >400 mg/dL, LDL cholesterol will not be calculated.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
LabCorp of America ​Monday-Friday ​1-3 days ​Nuclear Magnetic Resonance Spectroscopy
Reference Lab
Test Information

​Test measures LDL and HDL particle size and number of LDL particles. A lipid profile is also included based on NMR-derived lipid values. Medicare coverage is provided; contact private insurance carriers for coverage.
LDL particle number and size are similar for fasting and non-fasting specimens; however, triglycerides and VLDL results will be significantly higher with non-fasting samples.

Reference Range Information
Performing Location Reference Range
​LabCorp of America Refer to provided report.
Interpretation
​Interpretive report
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83704
Synonyms/Keywords
​NMR, Small dense LDL, HDL-C
Test Components
Historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides).
Ordering Applications
Ordering Application Description
​Centricity ​NMR Lipoprotein Quant #123638 
​Cerner ​NMR LipoProfile Test - LDL, HDL-C, and Triglycerides by NMR #123638
​COM​NMR Lipoprotein Quant #123638
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Overnight fasting preferred ​ ​Serum ​Red Top Tube (RTT) 2 mL ​1 mL
​Plasma ​EDTA Lavendar Top Tube (LTT) 2 mL ​1 mL
Collection Processing

​Patient should be fasting for 12 to 14 hours.

Collect specimen in NMR LipoTube (black-and-yellow-top tube), which is the preferred container. Plain red-top, green-top (heparin-no gel), or lavender-top (EDTA-no gel) tubes are also acceptable. Serum or plasma drawn in gel-barrier collection tubes other than the NMR LipoTube should not be used. The LipoTube is the only acceptable gel-barrier tube. Gently invert tube 8 to 10 times to mix contents and allow specimen to clot for 30 minutes upright at room temperature prior to centrifugation (Plasma tubes should not clot). Centrifuge specimen within two hours of collection at 1800xg for 10 to 15 minutes to separate serum/plasma from the red cells and to avoid red cell contamination during shipment. If the sample cannot be centrifuged immediately, the sample should be refrigerated (at 2ºC to 8ºC) and centrifuged within 24 hours of collection. Note: Centrifuging the specimen while still cold may negatively affect the migration of the gel to the serum/red cell interface and may increase the likelihood of specimens being contaminated with red cells during shipment. All specimens should be centrifuged by the client, prior to shipment to LabCorp, to ensure sample integrity. Do not open NMR LipoTube (black-and-yellow-top). Immediately after centrifugation, pipette separated red-top serum or green-top/lavender-top plasma into a transport tube and label accordingly (serum, heparin plasma, EDTA plasma). Keep samples refrigerated until shipment to the laboratory and ship with frozen cool packs.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​Refrigerate (preferred) ​6 days
Samples drawn at regional centers or outreach facilities should not be drawn on Friday.​ ​ ​
Rejection Criteria
Unspun Samples
​Plasma/Serum contaminated with red cells
​Citrated Plasma (Light Blue Top Tube)

​Gross Hemolysis

​Stored ambient for more than 24 hours
Sample more than 6 days old
Interference

​Refrigerate all acceptable tube types as soon as possible after centrifugation and within 24 hours of collection. Keep refrigerated prior to shipment, and ship on frozen cool packs. Do not store at room temperature. Do not freeze the sample. Sample is stable refrigerated for six days.

If triglyceride level is >400 mg/dL, LDL cholesterol will not be calculated.

Useful For
NMR LDL-P is a management tool used in appropriate high-risk patients (type 2 diabetes mellitus, metabolic syndrome, CVD risk equivalent, statin-treated patients) to adjudicate response to treatment and guide adjustment in therapy. It is used in conjunction with other lipid measurements and clinical evaluation to aid in the management of lipoprotein disorders associated with cardiovascular disease
Test Components
Historical reporting (LDL-P, LDL-C); insulin resistance and diabetes risk markers (large VLDL-P, small LDL-P, large HDL-P, VLDL size, LDL size, HDL size); insulin-resistance score; lipoprotein particle number (LDL-P); particle concentration and size (total HDL-P, small LDL-P, LDL size); standard lipid panel (total cholesterol, calculated LDL cholesterol, HDL cholesterol, triglycerides).
Reference Range Information
Performing Location Reference Range
​LabCorp of America Refer to provided report.
Interpretation
​Interpretive report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
LabCorp of America ​Monday-Friday ​1-3 days ​Nuclear Magnetic Resonance Spectroscopy
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83704
For most current information refer to the Marshfield Laboratory online reference manual.