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23064 Sweat Chloride

Sweat Chloride
Test Code: SWET-CL
Synonyms/Keywords
Iontophoresis, CF Sweat Test​
Useful For
Analysis of sweat for chloride is a reliable test to aid in the diagnosis of Cystic Fibrosis in conjunction with the presence of chronic obstructive respiratory disease and/or intestinal malabsorption.  This test generally becomes positive in affected infants between 3-5 weeks of age.   Test is not recommended on infants less than 48 hours old.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Sweat​ See Special Chemistry ​ Minimum acceptable sweat volume is 30 mg each arm​ Minimum acceptable sweat volume is 30 mg each arm​ Minimum acceptable sweat volume is 15 mg each arm​
Collection Processing Instructions
Call Genetics (ext. 17400) to schedule the test.  Special Chemistry personnel will collect the sweat specimen.  ​
Specimen Stability Information
Specimen Type Temperature Time
Sweat​ ​ Refrigerated​Up to 72 Hours​
Rejection Criteria
​​If less than 15 mg sweat is obtained, the ordering physician will be notified for rescheduling of the test.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday, started before 1400 hours​ 1-2 hours​ Iontophoresis stimulation, Chloride titration with ChloroCheck Chloridometer​
Reference Range Information
Performing Location Reference Range
Marshfield​
For individuals of all ages:
≤ 29 mmol/L:  CF unlikely
30-59 mmol/L:  intermediate
≥ 60 mmol/L:  indicative of CF.
 
Note: Sweat chloride values less than 30 mmol/L have been documented in genetically proven CF patients. Clinical correlation is necessary.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82438​ ​ ​ ​ Chloride, other source​
89230​ ​ ​ ​ Collection​
Synonyms/Keywords
Iontophoresis, CF Sweat Test​
Ordering Applications
Ordering Application Description
​COM ​Sweat Chloride
​Cerner Sweat Chloride (MFLD ONLY)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Sweat​ See Special Chemistry ​ Minimum acceptable sweat volume is 30 mg each arm​ Minimum acceptable sweat volume is 30 mg each arm​ Minimum acceptable sweat volume is 15 mg each arm​
Collection Processing
Call Genetics (ext. 17400) to schedule the test.  Special Chemistry personnel will collect the sweat specimen.  ​
Specimen Stability Information
Specimen Type Temperature Time
Sweat​ ​ Refrigerated​Up to 72 Hours​
Rejection Criteria
​​If less than 15 mg sweat is obtained, the ordering physician will be notified for rescheduling of the test.
Useful For
Analysis of sweat for chloride is a reliable test to aid in the diagnosis of Cystic Fibrosis in conjunction with the presence of chronic obstructive respiratory disease and/or intestinal malabsorption.  This test generally becomes positive in affected infants between 3-5 weeks of age.   Test is not recommended on infants less than 48 hours old.​
Reference Range Information
Performing Location Reference Range
Marshfield​
For individuals of all ages:
≤ 29 mmol/L:  CF unlikely
30-59 mmol/L:  intermediate
≥ 60 mmol/L:  indicative of CF.
 
Note: Sweat chloride values less than 30 mmol/L have been documented in genetically proven CF patients. Clinical correlation is necessary.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday, started before 1400 hours​ 1-2 hours​ Iontophoresis stimulation, Chloride titration with ChloroCheck Chloridometer​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82438​ ​ ​ ​ Chloride, other source​
89230​ ​ ​ ​ Collection​
For most current information refer to the Marshfield Laboratory online reference manual.