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23012 Vasoactive Intestinal Polypeptide, Plasma (VIP)

Vasoactive Intestinal Polypeptide, Plasma (VIP)
Test Code: VIP
Synonyms/Keywords
VIP (Vasoactive Intestinal Polypeptide)
Useful For
Detection of vasoactive intestinal polypeptide producing tumors in patients with chronic diarrheal diseases
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

Yes

(8 hours)​

Plasma ​EDTA Lavender Top Tube (LTT) ​1 mL ​0.55 mL
Collection Processing Instructions
1. Fasting (8 hours)
2. Spin down and immediately freeze in a plastic vial.
Additional Information: This test should not be requested on patients who have recently received radioactive material.​
Specimen Stability Information
Specimen Type Temperature Time
​Plasma EDTA ​Frozen ​90 days
Rejection Criteria
Hemolysis
Gross
​Lipemia
Gross
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Wednesday​ ​3 days
Radioimmunoassay (RIA)​
Reference Lab
Test Information
Vasoactive intestinal polypeptide (VIP) was originally isolated from porcine small intestine and was recognized by its potent vasodilator activity. This brain/gut hormone has widespread distribution and is present in neuronal cell bodies localized in the central nervous system, digestive, respiratory, and urogenital tracts, exocrine, thyroid, and adrenal glands. VIP has a wide scope of biological actions. The main effects of VIP include relaxation of smooth muscle (bronchial and vascular dilation), stimulation of gastrointestinal water and electrolyte secretion, and release of pancreatic hormones.
 
VIP producing tumors (VIPomas) are rare; most (90%) are located in the pancreas. Watery diarrhea, hypokalemia, and achlorhydria are key symptoms
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​<75 pg/mL
Interpretation
Values >75 pg/mL may indicate presence of enteropancreatic tumor causing hypersecretion of vasoactive intestinal polypeptide (VIP).
 
Values >200 pg/mL are strongly suggestive of VIP-producing tumors (VIPoma).
 
VIPoma is unlikely with a 24-hour stool volume <700 mL.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
84586
Synonyms/Keywords
VIP (Vasoactive Intestinal Polypeptide)
Ordering Applications
Ordering Application Description
​Centricity ​VIP (Vasoactive Intestinal Polypeptide)
​Cerner ​Vasoactive Intestinal Polypeptide (8150)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)

Yes

(8 hours)​

Plasma ​EDTA Lavender Top Tube (LTT) ​1 mL ​0.55 mL
Collection Processing
1. Fasting (8 hours)
2. Spin down and immediately freeze in a plastic vial.
Additional Information: This test should not be requested on patients who have recently received radioactive material.​
Specimen Stability Information
Specimen Type Temperature Time
​Plasma EDTA ​Frozen ​90 days
Rejection Criteria
Hemolysis
Gross
​Lipemia
Gross
Useful For
Detection of vasoactive intestinal polypeptide producing tumors in patients with chronic diarrheal diseases
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories ​<75 pg/mL
Interpretation
Values >75 pg/mL may indicate presence of enteropancreatic tumor causing hypersecretion of vasoactive intestinal polypeptide (VIP).
 
Values >200 pg/mL are strongly suggestive of VIP-producing tumors (VIPoma).
 
VIPoma is unlikely with a 24-hour stool volume <700 mL.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Wednesday​ ​3 days
Radioimmunoassay (RIA)​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
84586
For most current information refer to the Marshfield Laboratory online reference manual.