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23010 Varicella Zoster Virus (VZV) Immune Status

Varicella Zoster Virus (VZV) Immune Status
Test Code: VZI
Synonyms/Keywords
Varicella-zoster Antibody, Chickenpox
Useful For
This test qualitatively determines immune status for Varicella Zoster virus to in identifying nonimmune individuals for consideration of vaccination.  The test does include the numerical "Antibody Index (AI)" result.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen​ > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia
Gross icterus
​Plasma
​Heat inactivated sera
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday Less than 2 hours Multiplex Immnoassay/Biorad BioPlex 2200
Test Information
This test uses a multiplex flow fluorescence immunoassay to detect IgG-class antibodies directed against VZV.
Reference Range Information
Performing Location Reference Range
 Marshfield​

Reported as Positive, Equivocal or Negative

Positive:  AI > or = 1.1

Equivocal:  AI > 0.8 and < 1.1

Negative:  AI < or = 0.8​

Interpretation
T​his test is to be used only to establish serological status to VZV.  The reported AI value is for reference only.  This is a qualitative test and the AI is not indicative of the amount of antibody present, rather indicating that specific IgG-class antibodies were, or were not, detected, to determine if there was prior exposure or vaccination.
 
A positive test result may be due to immunization or natural infection.  A positive test has a high correlation with, but does not guarantee, immunity to VZV.
 
A negative test result indicates a lack of antibody to VZV marking the individual as a candidate for vaccination.
 
An equivocal result for this test indicates some reactivity of the individual's blood to the components of this test, but serological status cannot be determined.  In such cases the patient may be retested once to detect sero-conversion; alternatively, vaccination may be considered.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86787​
Synonyms/Keywords
Varicella-zoster Antibody, Chickenpox
Ordering Applications
Ordering Application Description
​Centricity ​Varicella Zoster Ab (Immune) (VZI)
​Cerner ​Varicella Zoster Antibody IgG
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 7 days​
Frozen​ > 7 days​
Rejection Criteria
Gross hemolysis
Gross lipemia
Gross icterus
​Plasma
​Heat inactivated sera
Useful For
This test qualitatively determines immune status for Varicella Zoster virus to in identifying nonimmune individuals for consideration of vaccination.  The test does include the numerical "Antibody Index (AI)" result.
Reference Range Information
Performing Location Reference Range
 Marshfield​

Reported as Positive, Equivocal or Negative

Positive:  AI > or = 1.1

Equivocal:  AI > 0.8 and < 1.1

Negative:  AI < or = 0.8​

Interpretation
T​his test is to be used only to establish serological status to VZV.  The reported AI value is for reference only.  This is a qualitative test and the AI is not indicative of the amount of antibody present, rather indicating that specific IgG-class antibodies were, or were not, detected, to determine if there was prior exposure or vaccination.
 
A positive test result may be due to immunization or natural infection.  A positive test has a high correlation with, but does not guarantee, immunity to VZV.
 
A negative test result indicates a lack of antibody to VZV marking the individual as a candidate for vaccination.
 
An equivocal result for this test indicates some reactivity of the individual's blood to the components of this test, but serological status cannot be determined.  In such cases the patient may be retested once to detect sero-conversion; alternatively, vaccination may be considered.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday Less than 2 hours Multiplex Immnoassay/Biorad BioPlex 2200
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86787​
For most current information refer to the Marshfield Laboratory online reference manual.