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23008 Vancomycin

Vancomycin
Test Code: VANCO
Useful For
Vancomycin is a glycopeptide antibiotic that is bactericidal against many gram-positive and some gram-negative cocci.​
Specimen Requirements
 
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​Serum​ or PlasmaSerum Separator Tube (SST)​Red Top Tube(RTT)​ or Lithium Heparin Plasma Separator Tube (PST)0.5 mL​0.2 mL​0.5 mL whole blood​
Collection Processing Instructions
Transport to lab on wet ice (ice with water or cold pack are both acceptable).
Serum should be removed from cells within 60 minutes.
EXACT DRAW TIME must be noted--both on the specimen label and on the request form/computer request.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 2 hours​
Freeze​ 1 year​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
​Eau Claire ​Monday through Sunday ​Less than 2 hours Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Flambeau Hospital​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Lakeview Medical Center​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​

Emit* 2000 Rate Assay/Beckman AU

​Minocqua​Monday through Sunday​Less than 2 hours​Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
​Neillsville​Monday through Sunday​Less than 2 hours​​Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Reference Range Information
Performing Location Reference Range
All Performing Sites

Reference Range: Trough concentrations only

Therapeutic concentrations: 10-15 ug/mL

Serious infections: 15-20 ug/mL

Toxic levels: >=80 ug/mL​

See Critical Value List for list of current critical values​​
Interpretation

1) Vancomycin trough concentrations should always be maintained at >10 ug/mL to avoid the development of resistance.
2) For serious Staphylococcus aureus infections such as septicemia, infective endocarditis, osteomyelitis, meningitis, pneumonia and severe SSTI (necrotizing fascititis), vancomycin trough concentrations of 15-20 ug/mL are recommeneded.
3) Vancomycin induced nephrotoxicity is indicated when serum creatinine increase of 0.5 mg/dL or 50% from baseline (whichever greater) is observed after several days of therapy in the absence of an alternative explanantion. Recommend a minimum of two or three consecutive serum creatinine concentrations to monitor possible nephrotoxicity during the course of therapy.

Trough concentrations are most accurate and recommended for therapeutic monitoring of Vancomycin preferably obtained just prior to the next dose at steady-state condition (just before the fourth dose with normal renal function). Evidence does not support monitoring peak concentrations to decrease the frequency of nephrotoxicity.​

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80202​
Ordering Applications
Ordering Application Description
​Centricity ​Vancomycin
​Cerner ​Vancomycin Level
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
 
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​Serum​ or PlasmaSerum Separator Tube (SST)​Red Top Tube(RTT)​ or Lithium Heparin Plasma Separator Tube (PST)0.5 mL​0.2 mL​0.5 mL whole blood​
Collection Processing
Transport to lab on wet ice (ice with water or cold pack are both acceptable).
Serum should be removed from cells within 60 minutes.
EXACT DRAW TIME must be noted--both on the specimen label and on the request form/computer request.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 2 hours​
Freeze​ 1 year​
Useful For
Vancomycin is a glycopeptide antibiotic that is bactericidal against many gram-positive and some gram-negative cocci.​
Reference Range Information
Performing Location Reference Range
All Performing Sites

Reference Range: Trough concentrations only

Therapeutic concentrations: 10-15 ug/mL

Serious infections: 15-20 ug/mL

Toxic levels: >=80 ug/mL​

See Critical Value List for list of current critical values​​
Interpretation

1) Vancomycin trough concentrations should always be maintained at >10 ug/mL to avoid the development of resistance.
2) For serious Staphylococcus aureus infections such as septicemia, infective endocarditis, osteomyelitis, meningitis, pneumonia and severe SSTI (necrotizing fascititis), vancomycin trough concentrations of 15-20 ug/mL are recommeneded.
3) Vancomycin induced nephrotoxicity is indicated when serum creatinine increase of 0.5 mg/dL or 50% from baseline (whichever greater) is observed after several days of therapy in the absence of an alternative explanantion. Recommend a minimum of two or three consecutive serum creatinine concentrations to monitor possible nephrotoxicity during the course of therapy.

Trough concentrations are most accurate and recommended for therapeutic monitoring of Vancomycin preferably obtained just prior to the next dose at steady-state condition (just before the fourth dose with normal renal function). Evidence does not support monitoring peak concentrations to decrease the frequency of nephrotoxicity.​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
​Eau Claire ​Monday through Sunday ​Less than 2 hours Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Flambeau Hospital​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Lakeview Medical Center​ ​Monday through Sunday​ ​Less than 2 hours​ Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​

Emit* 2000 Rate Assay/Beckman AU

​Minocqua​Monday through Sunday​Less than 2 hours​Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
​Neillsville​Monday through Sunday​Less than 2 hours​​Turbidimetric Inhibition Immunoassay Method/Siemens Dimension
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80202​
For most current information refer to the Marshfield Laboratory online reference manual.