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23001 Prothrombin Gene Mutation

Prothrombin Gene Mutation
Test Code: PTG
Synonyms/Keywords
​ PTG 20210, Prothrombin Gene Mutation (PTG), Hypercoagulability, Thrombophilia
Useful For
​People with Prothrombin G20210A mutations have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT).  Prothrombin G20210A tests are ordered when it is suspected that a person has an inherited risk factor for thrombosis, for example, in someone who has a first DVT or venous thromboembolism (VTE) before age 50 or in an unusual part of the body.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA Lavender Top Tube (LTT)​ ​Citrated Blue Top Tube (BTT) 3.0 mL​ 1.0 mL​
Collection Processing Instructions
​This tube should be drawn at least 90% full. Invert tube completely three or four times to mix. Do not shake. Do not open tube. Note: The blood specimen tube must not be opened prior to analysis.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​ Room Temperature ​< 24 hours
​Refrigerate​<= 15 days
​Frozen​<= 3 months
Rejection Criteria
Clotted
​Specimen tubes that have been opened or previously processed
​Unacceptable temperature storage
​Heparinized blood
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday 6-8 hours​ ​PCR/Genetic mutation
Test Information

Heterozygous for Prothrombin G20210A: the relative risk of venous thrombosis is about 3 to 4-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.

Homozygous for Prothrombin G20210A:  This is a rare finding occurring roughly 1 in 10,000 people of European descent.  It probably confers some degrees of hypercoagulability, but there are too few cases to date to calculate risk.  The magnitude of the risk associated with homozygosity for this mutation has not been fully established but is likely to be greater than the 3 to 4-fold increased risk attributed to heterozygosity.

Reference Range Information
Performing Location Reference Range
​Marshfield ​Heterozygous, Homozygous, or Normal (No evidence of PTG mutation)
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81240 ​ ​ ​Prothrombin Gene Mutation ​
Synonyms/Keywords
​ PTG 20210, Prothrombin Gene Mutation (PTG), Hypercoagulability, Thrombophilia
Ordering Applications
Ordering Application Description
​Centricity ​Prothrombin G20210A Gene
​Cerner ​Prothrombin Gene Mutation 20210A
​COM ​Prothrombin Gene Mutation
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA Lavender Top Tube (LTT)​ ​Citrated Blue Top Tube (BTT) 3.0 mL​ 1.0 mL​
Collection Processing
​This tube should be drawn at least 90% full. Invert tube completely three or four times to mix. Do not shake. Do not open tube. Note: The blood specimen tube must not be opened prior to analysis.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​ Room Temperature ​< 24 hours
​Refrigerate​<= 15 days
​Frozen​<= 3 months
Rejection Criteria
Clotted
​Specimen tubes that have been opened or previously processed
​Unacceptable temperature storage
​Heparinized blood
Useful For
​People with Prothrombin G20210A mutations have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT).  Prothrombin G20210A tests are ordered when it is suspected that a person has an inherited risk factor for thrombosis, for example, in someone who has a first DVT or venous thromboembolism (VTE) before age 50 or in an unusual part of the body.
Reference Range Information
Performing Location Reference Range
​Marshfield ​Heterozygous, Homozygous, or Normal (No evidence of PTG mutation)
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday 6-8 hours​ ​PCR/Genetic mutation
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81240 ​ ​ ​Prothrombin Gene Mutation ​
For most current information refer to the Marshfield Laboratory online reference manual.