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22928 Topiramate, Serum (TOPI)

Topiramate, Serum (TOPI)
Test Code: TOPIRSO
Synonyms/Keywords
Topamax (Topiramate), Topiramate (Topamax)
Useful For
Monitoring serum concentrations of topiramate
 
Assessing compliance
 
Assessing potential toxicity​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​1 mL ​0.5 mL
Collection Processing Instructions
​Submit specimen in a plastic vial
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen ​28 days
​Refrigerated (preferred) ​28 days
​Ambient ​28 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Saturday​ ​1 day
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Test Information
​ If dosage and dosing information are provided, they will be included on report to enhance clinical interpretation.
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories
Depends on clinical use:
 
Anticonvulsant: 5.0-20.0 mcg/mL
Psychiatric: 2.0-8.0 mcg/mL
Interpretation

Most individuals display optimal response to topiramate with serum levels 5.0 to 20.0 mcg/mL when used to control seizures. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 

Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose).

Toxic levels have not been well established.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80201
Synonyms/Keywords
Topamax (Topiramate), Topiramate (Topamax)
Ordering Applications
Ordering Application Description
​Centricity ​Topiramate, Serum (81546)
​Cerner ​Topiramate Level (81546)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​1 mL ​0.5 mL
Collection Processing
​Submit specimen in a plastic vial
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen ​28 days
​Refrigerated (preferred) ​28 days
​Ambient ​28 days
Useful For
Monitoring serum concentrations of topiramate
 
Assessing compliance
 
Assessing potential toxicity​
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories
Depends on clinical use:
 
Anticonvulsant: 5.0-20.0 mcg/mL
Psychiatric: 2.0-8.0 mcg/mL
Interpretation

Most individuals display optimal response to topiramate with serum levels 5.0 to 20.0 mcg/mL when used to control seizures. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 

Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose).

Toxic levels have not been well established.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Monday through Saturday​ ​1 day
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80201
For most current information refer to the Marshfield Laboratory online reference manual.