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22887 Microalbumin, Urine, 24HR or Timed Overnight

Microalbumin, Urine, 24HR or Timed Overnight
Test Code: MA
Synonyms/Keywords
​Albumin/Creatinine ratio, Microalbumin-random urine, Albumin in urine
Test Components
​Albumin and creatinine
Useful For
​The urinary albumin level is an excellent predictor of progression to nephropathy in both insulin dependent and non-insulin dependent diabetes. Measurement of albumin excretion in an overnight collection of urine is generally considered the best measurement; however, 24 hour urines and random urines may also be used.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No Urine, Overnight or 24 hour​ 10 mL urine aliquot tube​ Sage cup ​ 10 mL​ 6 mL​ 3 mL​
Collection Processing Instructions
​Collect an overnight (typically 8 hour, starting in the evening and ending in the morning) urine sample without preservative, recording the duration and total volume.   Unpreserved 24 hour urine specimens are also acceptable.  Times for 24 hour collection should be between 22-26 hours.
Specimen Stability Information
Specimen Type Temperature Time
​Urine Refrigerate​ 7 days​
Rejection Criteria
Specimens visibly contaminated with red blood cells
Frozen samples​
Specimens collected with acid preservatives​
Specimens from patients with urinary tract infections, or exhibiting significant bacterial growth​
Interference
​If a technologist suspects a specimen to be contaminated with blood, either by visual inspection or results that are extremely high compared to previous sampling, routine urinalysis dipsticks may be used to screen the sample for blood.  If blood is present at a level of 3+ or more, an asterisk will be entered in the result field, and a comment will be entered instead of a result: “Unable to accurately quantitate albumin in urine due to specimen contamination with blood. Charges will be credited.”
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
Reference Range Information
Performing Location Reference Range
Marshfield​

AER (overnight collection): 0-20 ug albumin/minute

Albumin/24 hours (24 hour collection): 0-30 mg albumin/24 hours​

Interpretation
​Microalbuminria is a reversible condition characterized by increased urinary excretion of albumin in the absence of overt proteinuria.  It occurs in diabetic and hypertensive patients and is generally treatable by blood pressure-lowering medications.  Using this therapy, progression to an irreversible state of macroalbuminuria can be prevented or delayed for a decade or more.  Conventional dipstick and acid precipitation tests for detecting protein in urine lack the sensitivity required to delineate this condition.  Dipsticks may yield negative results even when the albumin excretion rate is 10 or 20 times normal.  Nephelometry enables sufficient sensitivity to detect albumin at these levels.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82043​
Synonyms/Keywords
​Albumin/Creatinine ratio, Microalbumin-random urine, Albumin in urine
Test Components
​Albumin and creatinine
Ordering Applications
Ordering Application Description
​Centricity ​MicAlb-24hr
​Cerner ​Microalbumin Level 24 Hour Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No Urine, Overnight or 24 hour​ 10 mL urine aliquot tube​ Sage cup ​ 10 mL​ 6 mL​ 3 mL​
Collection Processing
​Collect an overnight (typically 8 hour, starting in the evening and ending in the morning) urine sample without preservative, recording the duration and total volume.   Unpreserved 24 hour urine specimens are also acceptable.  Times for 24 hour collection should be between 22-26 hours.
Specimen Stability Information
Specimen Type Temperature Time
​Urine Refrigerate​ 7 days​
Rejection Criteria
Specimens visibly contaminated with red blood cells
Frozen samples​
Specimens collected with acid preservatives​
Specimens from patients with urinary tract infections, or exhibiting significant bacterial growth​
Interference
​If a technologist suspects a specimen to be contaminated with blood, either by visual inspection or results that are extremely high compared to previous sampling, routine urinalysis dipsticks may be used to screen the sample for blood.  If blood is present at a level of 3+ or more, an asterisk will be entered in the result field, and a comment will be entered instead of a result: “Unable to accurately quantitate albumin in urine due to specimen contamination with blood. Charges will be credited.”
Useful For
​The urinary albumin level is an excellent predictor of progression to nephropathy in both insulin dependent and non-insulin dependent diabetes. Measurement of albumin excretion in an overnight collection of urine is generally considered the best measurement; however, 24 hour urines and random urines may also be used.
Test Components
​Albumin and creatinine
Reference Range Information
Performing Location Reference Range
Marshfield​

AER (overnight collection): 0-20 ug albumin/minute

Albumin/24 hours (24 hour collection): 0-30 mg albumin/24 hours​

Interpretation
​Microalbuminria is a reversible condition characterized by increased urinary excretion of albumin in the absence of overt proteinuria.  It occurs in diabetic and hypertensive patients and is generally treatable by blood pressure-lowering medications.  Using this therapy, progression to an irreversible state of macroalbuminuria can be prevented or delayed for a decade or more.  Conventional dipstick and acid precipitation tests for detecting protein in urine lack the sensitivity required to delineate this condition.  Dipsticks may yield negative results even when the albumin excretion rate is 10 or 20 times normal.  Nephelometry enables sufficient sensitivity to detect albumin at these levels.
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 6-8 hours​ Turbidimetric method/The Binding Site Optilite analyzer​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82043​
For most current information refer to the Marshfield Laboratory online reference manual.