Skip Ribbon Commands
Skip to main content
Sign In

22814 Lamotrigine

Lamotrigine
Test Code: LAMO
Synonyms/Keywords
Lamictal​
Useful For
Monitoring lamotrigine.  Lamotrigine is an anticonvulsant drugs used for the treatment of epilepsy.  In addition to its anticonvulsant properties, it is approved for the maintenance treatment of bipolar type 1 disorder.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​

Serum ​

Red Top Tube (RTT)​
 
0.5 mL​ 0.5 mL​ 0.3 mL​
Collection Processing Instructions
Indicate collection time​
Specimen Stability Information
Specimen Type Temperature Time
​ Serum​ ​​ ​Ambient ​48 hrs
Refrigerate​ 2 weeks
Frozen 2 weeks
Rejection Criteria
​Specimens collected in a serum or plasma separator tube
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 1 day​
UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​​
Testing may be batched and set up on alternative days of the week as needed.​ ​ ​
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Reference Range Information
Performing Location Reference Range
Marshfield​

No reference range is established for lamotrigine

Minimum trough levels of 1-3 ug/mL are required for efficacy

Levels as high as >= 10 ug/mL are used clinically.

Optimal dosing cannot be currently established based on blood levels​

​ See Critical Value List for list of current critical values​
Interpretation

With monotherapy, lamotrigine has relatively few side-effects and generally doesn't lead to toxicity.  However, clearance is altered by serveral other compounds and combination therapy with other anticonvulant drugs can have a substantial effect on the clearance of this drug.​

Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80175
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
Lamictal​
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​

Serum ​

Red Top Tube (RTT)​
 
0.5 mL​ 0.5 mL​ 0.3 mL​
Collection Processing
Indicate collection time​
Specimen Stability Information
Specimen Type Temperature Time
​ Serum​ ​​ ​Ambient ​48 hrs
Refrigerate​ 2 weeks
Frozen 2 weeks
Rejection Criteria
​Specimens collected in a serum or plasma separator tube
Useful For
Monitoring lamotrigine.  Lamotrigine is an anticonvulsant drugs used for the treatment of epilepsy.  In addition to its anticonvulsant properties, it is approved for the maintenance treatment of bipolar type 1 disorder.​
Reference Range Information
Performing Location Reference Range
Marshfield​

No reference range is established for lamotrigine

Minimum trough levels of 1-3 ug/mL are required for efficacy

Levels as high as >= 10 ug/mL are used clinically.

Optimal dosing cannot be currently established based on blood levels​

​ See Critical Value List for list of current critical values​
Interpretation

With monotherapy, lamotrigine has relatively few side-effects and generally doesn't lead to toxicity.  However, clearance is altered by serveral other compounds and combination therapy with other anticonvulant drugs can have a substantial effect on the clearance of this drug.​

Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 1 day​
UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​​
Testing may be batched and set up on alternative days of the week as needed.​ ​ ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80175
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.