No reference range is established for lamotrigine
Minimum trough levels of 1-3 ug/mL are required for efficacy
Levels as high as >= 10 ug/mL are used clinically.
Optimal dosing cannot be currently established based on blood levels
With monotherapy, lamotrigine has relatively few side-effects and generally doesn't lead to toxicity. However, clearance is altered by serveral other compounds and combination therapy with other anticonvulant drugs can have a substantial effect on the clearance of this drug.