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22736 Hepatitis Panel, Acute

Hepatitis Panel, Acute
Test Code: AS
Synonyms/Keywords
Panel, Hepatitis Acute​
Test Components
Hepatitis A Antibody IgM, Hepatitis B Surface Antigen, Hepatitis B Core Antibody IgM and Hepatitis C Antibody.
Useful For
In the diagnosis of acute viral hepatitis caused by the three most common viruses in the USA: hepatitis A, hepatitis B, & hepatitis C.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​2 mL​1.5 mL​1 mL​
Collection Processing Instructions
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites: Please send samples to Marshfield frozen. 
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.  It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
​​
Serum​ ​		​Ambient
​​<8 hours
​​Refrigerate​
 <48 hours
Frozen​ at -20 °C 6 months
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay (A-M, ABC-M, HAA).
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Chemiluminometric Immunoassays/Siemens Centaur
Test Information

Acute hepatitis may be caused by viral infection, non-viral infection, or non-infectious causes. Hepatitis A is transmitted by the oral-fecal route, while hepatitis B & hepatitis C are primarily borne by blood and other body fluids. While all three viruses can cause acute viral hepatitis, only B & C can progress to a chronic infection.

Limitations:
• The results determined by different assays from different manufacturers can vary due to differences in assay specificities and cannot be used interchangeably.
• For other limitations consult individual test reference assay entries.

Reference Range Information
Performing Location Reference Range
Marshfield​ Tests reported as "Reactive" or "Non-reactive"​
Interpretation

Results may be interpreted as follows: 

  • Reactive hepatitis A IgM antibody is indicative of acute infection. 
  • Reactive hepatitis B surface antigen and reactive hepatitis B core IgM antibody results indicates acute hepatitis B infection. 
  • Reactive hepatitis B surface antigen and non-reactive hepatitis B core IgM antibody is indicative of chronic hepatitis B. 
  • Reactive hepatitis C antibody indicates either acute or chronic hepatitis C infection. The Hepatitis C Virus RNA, Quantitative test (test code HCVQT) may be used to detect ongoing viral replication.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80074 ​ ​ ​ ​ ​
Synonyms/Keywords
Panel, Hepatitis Acute​
Test Components
Hepatitis A Antibody IgM, Hepatitis B Surface Antigen, Hepatitis B Core Antibody IgM and Hepatitis C Antibody.
Ordering Applications
Ordering Application Description
​Centricity ​Hep. Scn-Acture
​Cerner ​Hepatitis Panel, Acute
​Clinical Order Manager ​Hep Panel, Acute
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​2 mL​1.5 mL​1 mL​
Collection Processing
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites: Please send samples to Marshfield frozen. 
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.  It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
​​
Serum​ ​		​Ambient
​​<8 hours
​​Refrigerate​
 <48 hours
Frozen​ at -20 °C 6 months
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay (A-M, ABC-M, HAA).
Useful For
In the diagnosis of acute viral hepatitis caused by the three most common viruses in the USA: hepatitis A, hepatitis B, & hepatitis C.
Test Components
Hepatitis A Antibody IgM, Hepatitis B Surface Antigen, Hepatitis B Core Antibody IgM and Hepatitis C Antibody.
Reference Range Information
Performing Location Reference Range
Marshfield​ Tests reported as "Reactive" or "Non-reactive"​
Interpretation

Results may be interpreted as follows: 

  • Reactive hepatitis A IgM antibody is indicative of acute infection. 
  • Reactive hepatitis B surface antigen and reactive hepatitis B core IgM antibody results indicates acute hepatitis B infection. 
  • Reactive hepatitis B surface antigen and non-reactive hepatitis B core IgM antibody is indicative of chronic hepatitis B. 
  • Reactive hepatitis C antibody indicates either acute or chronic hepatitis C infection. The Hepatitis C Virus RNA, Quantitative test (test code HCVQT) may be used to detect ongoing viral replication.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Chemiluminometric Immunoassays/Siemens Centaur
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80074 ​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.